STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
emrKMultidrug resistance efflux pump membrane fusion protein; Part of the tripartite efflux system EmrYK-TolC, which confers resistance to various drugs (387 aa)    
Predicted Functional Partners:
emrY
Mfs transporter, dha2 family, multidrug resistance protein; Part of the tripartite efflux system EmrYK-TolC, which confers resistance to various drugs
 
 
 0.999
emrB
Mfs transporter, dha2 family, multidrug resistance protein; Part of the tripartite efflux system EmrAB-TolC, which confers resistance to antibiotics such as CCCP, FCCP, 2,4-dinitrophenol and nalidixic acid
 
 
 0.945
tolC
Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells
   
 0.938
mdtE
Anaerobic multidrug efflux transporter, arca-regulated; Part of the tripartite efflux system MdtEF-TolC, which confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzalkonium
  
 
 0.912
acrD
Multidrug efflux pump rnd permease acrd; Participates in the efflux of aminoglycosides. Confers resistance to a variety of these substances
 
 
 0.863
mdtA
Multidrug efflux pump membrane fusion protein mdta; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdtABC requires TolC for its function
  
 
 0.858
emrD
Mfs transporter, dha1 family, 2-module integral membrane pump emrd; Multidrug resistance pump that participates in a low energy shock adaptive response
   
  
 0.845
mdtH
Mfs transporter, dha1 family, multidrug resistance protein; Confers resistance to norfloxacin and enoxacin
      
 0.827
acrB
Multidrug efflux pump rnd permease acrb; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates
 
  
 0.775
mdtP
Putative multidrug efflux pump outer membrane channel; Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride
  
 0.746
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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