Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| bglJ | leuO | b4366 | b0076 | Luxr family transcriptional regulator, regulator of transport and utilization of aryl beta-glucosides; A crytic transcriptional activator. When its expression is induced it relieves H-NS repression of the bgl operon. Acts independently of transcription factor LeuO | Lysr family transcriptional regulator, transcriptional activator for leuabcd operon; A global transcription factor. Activates transcription of the 9 following operons; yjjQ-bglJ, yjjP, acrEF, ybdO, yjcRQP, casABCDE12, rhsD-ybbC, fepE and gltF, in most cases it probably interferes with silencing by H-NS and activates transcription. Represses transcription of the 3 following operons; uxaCA, sdaCB and btsT. H-NS repression of the bgl operon, leading to the ability to metabolize some beta- glucosides. It also directly activates the bgl operon. Activation is H- NS and BglJ-RcsB independent | 0.912 |
| bglJ | stpA | b4366 | b2669 | Luxr family transcriptional regulator, regulator of transport and utilization of aryl beta-glucosides; A crytic transcriptional activator. When its expression is induced it relieves H-NS repression of the bgl operon. Acts independently of transcription factor LeuO | Dna-binding transcriptional repressor stpa with rna chaperone activity; A DNA-binding protein that acts in a fashion similar to H-NS protein upon overexpression, represses a number of genes including the cryptic blg operon, hns, papB and the proU locus . A subset of H-NS/StpA-regulated genes also require Hha for repression; Hha and Cnu (YdgT) increases the number of genes DNA bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex . Repression can be inhibited by dominant-negative mutants of StpA or H-NS | 0.732 |
| cnu | hns | b1625 | b1237 | Nucleoid-associated oric-binding protein; Modifies the set of genes regulated by H-NS; Hha and Cnu (YdgT) increase the number of genes bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex on DNA . The complex formed with H-NS binds to the specific 26-bp cnb site in the origin of replication oriC . Can complement, at least partially, the absence of the Hha protein in hha mutants | A DNA-binding protein implicated in transcriptional repression (silencing) Also involved in bacterial chromosome organization and compaction . H-NS binds tightly to AT-rich dsDNA and inhibits transcription Binds upstream and downstream of initiating RNA polymerase, trapping it in a loop and preventing transcription . Binds to hundreds of sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome . Many of these loci were horizontally transferred (HTG); this offers the selective advantage of silencing foreign DNA while keeping it i [...] | 0.925 |
| cnu | stpA | b1625 | b2669 | Nucleoid-associated oric-binding protein; Modifies the set of genes regulated by H-NS; Hha and Cnu (YdgT) increase the number of genes bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex on DNA . The complex formed with H-NS binds to the specific 26-bp cnb site in the origin of replication oriC . Can complement, at least partially, the absence of the Hha protein in hha mutants | Dna-binding transcriptional repressor stpa with rna chaperone activity; A DNA-binding protein that acts in a fashion similar to H-NS protein upon overexpression, represses a number of genes including the cryptic blg operon, hns, papB and the proU locus . A subset of H-NS/StpA-regulated genes also require Hha for repression; Hha and Cnu (YdgT) increases the number of genes DNA bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex . Repression can be inhibited by dominant-negative mutants of StpA or H-NS | 0.952 |
| fis | hfq | b3261 | b4172 | Fis family transcriptional regulator, factor for inversion stimulation protein; Activates ribosomal RNA transcription, as well other genes. Plays a direct role in upstream activation of rRNA promoters. Binds to a recombinational enhancer sequence that is required to stimulate hin- mediated DNA inversion. Prevents initiation of DNA replication from oriC. Binds to hundreds of transcriptionally active and inactive AT- rich sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome | Rna-binding protein hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Involved in the regulation of stress responses mediated by the sigma factors RpoS, sigma-E and sigma-32 . Binds with high specificity to tRNAs . Binds sRNA antitoxin RalA . In vitro, stimulates synthesis of long tails by poly(A) polymerase I . Required for RNA phage Qbeta replication . Seems to play a role in persister cell formation; upon overexpression decreas [...] | 0.835 |
| fis | hha | b3261 | b0460 | Fis family transcriptional regulator, factor for inversion stimulation protein; Activates ribosomal RNA transcription, as well other genes. Plays a direct role in upstream activation of rRNA promoters. Binds to a recombinational enhancer sequence that is required to stimulate hin- mediated DNA inversion. Prevents initiation of DNA replication from oriC. Binds to hundreds of transcriptionally active and inactive AT- rich sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome | Haemolysin expression modulating protein; Down-regulates hemolysin (hly) expression in complex with H- NS . Stimulates transposition events in vivo . Modifies the set of genes regulated by H-NS; Hha and Cnu (YdgT) increase the number of genes DNA bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex . Binds DNA and influences DNA topology in response to environmental stimuli; does not however interact with DNA in the absence of H-NS . Involved in persister cell formation, acting downstream of mRNA interferase (toxin) MqsR . Decreases biofilm formation by [...] | 0.517 |
| fis | lrp | b3261 | b0889 | Fis family transcriptional regulator, factor for inversion stimulation protein; Activates ribosomal RNA transcription, as well other genes. Plays a direct role in upstream activation of rRNA promoters. Binds to a recombinational enhancer sequence that is required to stimulate hin- mediated DNA inversion. Prevents initiation of DNA replication from oriC. Binds to hundreds of transcriptionally active and inactive AT- rich sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome | Lrp/asnc family transcriptional regulator, leucine-responsive regulatory protein; Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes | 0.863 |
| fis | seqA | b3261 | b0687 | Fis family transcriptional regulator, factor for inversion stimulation protein; Activates ribosomal RNA transcription, as well other genes. Plays a direct role in upstream activation of rRNA promoters. Binds to a recombinational enhancer sequence that is required to stimulate hin- mediated DNA inversion. Prevents initiation of DNA replication from oriC. Binds to hundreds of transcriptionally active and inactive AT- rich sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome | Seqa, negative modulator of initiation of replication; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. Can also bind to hemimethylated GATC sequences outside of oriC region. Binds, with less affinity, to fully methylated G [...] | 0.734 |
| fis | stpA | b3261 | b2669 | Fis family transcriptional regulator, factor for inversion stimulation protein; Activates ribosomal RNA transcription, as well other genes. Plays a direct role in upstream activation of rRNA promoters. Binds to a recombinational enhancer sequence that is required to stimulate hin- mediated DNA inversion. Prevents initiation of DNA replication from oriC. Binds to hundreds of transcriptionally active and inactive AT- rich sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome | Dna-binding transcriptional repressor stpa with rna chaperone activity; A DNA-binding protein that acts in a fashion similar to H-NS protein upon overexpression, represses a number of genes including the cryptic blg operon, hns, papB and the proU locus . A subset of H-NS/StpA-regulated genes also require Hha for repression; Hha and Cnu (YdgT) increases the number of genes DNA bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex . Repression can be inhibited by dominant-negative mutants of StpA or H-NS | 0.732 |
| fis | yciS | b3261 | b1279 | Fis family transcriptional regulator, factor for inversion stimulation protein; Activates ribosomal RNA transcription, as well other genes. Plays a direct role in upstream activation of rRNA promoters. Binds to a recombinational enhancer sequence that is required to stimulate hin- mediated DNA inversion. Prevents initiation of DNA replication from oriC. Binds to hundreds of transcriptionally active and inactive AT- rich sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome | DUF1049 family inner membrane protein, function unknown; Involved in the assembly of lipopolysaccharide (LPS) | 0.468 |
| hfq | fis | b4172 | b3261 | Rna-binding protein hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Involved in the regulation of stress responses mediated by the sigma factors RpoS, sigma-E and sigma-32 . Binds with high specificity to tRNAs . Binds sRNA antitoxin RalA . In vitro, stimulates synthesis of long tails by poly(A) polymerase I . Required for RNA phage Qbeta replication . Seems to play a role in persister cell formation; upon overexpression decreas [...] | Fis family transcriptional regulator, factor for inversion stimulation protein; Activates ribosomal RNA transcription, as well other genes. Plays a direct role in upstream activation of rRNA promoters. Binds to a recombinational enhancer sequence that is required to stimulate hin- mediated DNA inversion. Prevents initiation of DNA replication from oriC. Binds to hundreds of transcriptionally active and inactive AT- rich sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome | 0.835 |
| hfq | lrp | b4172 | b0889 | Rna-binding protein hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Involved in the regulation of stress responses mediated by the sigma factors RpoS, sigma-E and sigma-32 . Binds with high specificity to tRNAs . Binds sRNA antitoxin RalA . In vitro, stimulates synthesis of long tails by poly(A) polymerase I . Required for RNA phage Qbeta replication . Seems to play a role in persister cell formation; upon overexpression decreas [...] | Lrp/asnc family transcriptional regulator, leucine-responsive regulatory protein; Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes | 0.725 |
| hfq | stpA | b4172 | b2669 | Rna-binding protein hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Involved in the regulation of stress responses mediated by the sigma factors RpoS, sigma-E and sigma-32 . Binds with high specificity to tRNAs . Binds sRNA antitoxin RalA . In vitro, stimulates synthesis of long tails by poly(A) polymerase I . Required for RNA phage Qbeta replication . Seems to play a role in persister cell formation; upon overexpression decreas [...] | Dna-binding transcriptional repressor stpa with rna chaperone activity; A DNA-binding protein that acts in a fashion similar to H-NS protein upon overexpression, represses a number of genes including the cryptic blg operon, hns, papB and the proU locus . A subset of H-NS/StpA-regulated genes also require Hha for repression; Hha and Cnu (YdgT) increases the number of genes DNA bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex . Repression can be inhibited by dominant-negative mutants of StpA or H-NS | 0.694 |
| hha | fis | b0460 | b3261 | Haemolysin expression modulating protein; Down-regulates hemolysin (hly) expression in complex with H- NS . Stimulates transposition events in vivo . Modifies the set of genes regulated by H-NS; Hha and Cnu (YdgT) increase the number of genes DNA bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex . Binds DNA and influences DNA topology in response to environmental stimuli; does not however interact with DNA in the absence of H-NS . Involved in persister cell formation, acting downstream of mRNA interferase (toxin) MqsR . Decreases biofilm formation by [...] | Fis family transcriptional regulator, factor for inversion stimulation protein; Activates ribosomal RNA transcription, as well other genes. Plays a direct role in upstream activation of rRNA promoters. Binds to a recombinational enhancer sequence that is required to stimulate hin- mediated DNA inversion. Prevents initiation of DNA replication from oriC. Binds to hundreds of transcriptionally active and inactive AT- rich sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome | 0.517 |
| hha | hns | b0460 | b1237 | Haemolysin expression modulating protein; Down-regulates hemolysin (hly) expression in complex with H- NS . Stimulates transposition events in vivo . Modifies the set of genes regulated by H-NS; Hha and Cnu (YdgT) increase the number of genes DNA bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex . Binds DNA and influences DNA topology in response to environmental stimuli; does not however interact with DNA in the absence of H-NS . Involved in persister cell formation, acting downstream of mRNA interferase (toxin) MqsR . Decreases biofilm formation by [...] | A DNA-binding protein implicated in transcriptional repression (silencing) Also involved in bacterial chromosome organization and compaction . H-NS binds tightly to AT-rich dsDNA and inhibits transcription Binds upstream and downstream of initiating RNA polymerase, trapping it in a loop and preventing transcription . Binds to hundreds of sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome . Many of these loci were horizontally transferred (HTG); this offers the selective advantage of silencing foreign DNA while keeping it i [...] | 0.985 |
| hha | stpA | b0460 | b2669 | Haemolysin expression modulating protein; Down-regulates hemolysin (hly) expression in complex with H- NS . Stimulates transposition events in vivo . Modifies the set of genes regulated by H-NS; Hha and Cnu (YdgT) increase the number of genes DNA bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex . Binds DNA and influences DNA topology in response to environmental stimuli; does not however interact with DNA in the absence of H-NS . Involved in persister cell formation, acting downstream of mRNA interferase (toxin) MqsR . Decreases biofilm formation by [...] | Dna-binding transcriptional repressor stpa with rna chaperone activity; A DNA-binding protein that acts in a fashion similar to H-NS protein upon overexpression, represses a number of genes including the cryptic blg operon, hns, papB and the proU locus . A subset of H-NS/StpA-regulated genes also require Hha for repression; Hha and Cnu (YdgT) increases the number of genes DNA bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex . Repression can be inhibited by dominant-negative mutants of StpA or H-NS | 0.947 |
| hns | cnu | b1237 | b1625 | A DNA-binding protein implicated in transcriptional repression (silencing) Also involved in bacterial chromosome organization and compaction . H-NS binds tightly to AT-rich dsDNA and inhibits transcription Binds upstream and downstream of initiating RNA polymerase, trapping it in a loop and preventing transcription . Binds to hundreds of sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome . Many of these loci were horizontally transferred (HTG); this offers the selective advantage of silencing foreign DNA while keeping it i [...] | Nucleoid-associated oric-binding protein; Modifies the set of genes regulated by H-NS; Hha and Cnu (YdgT) increase the number of genes bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex on DNA . The complex formed with H-NS binds to the specific 26-bp cnb site in the origin of replication oriC . Can complement, at least partially, the absence of the Hha protein in hha mutants | 0.925 |
| hns | hha | b1237 | b0460 | A DNA-binding protein implicated in transcriptional repression (silencing) Also involved in bacterial chromosome organization and compaction . H-NS binds tightly to AT-rich dsDNA and inhibits transcription Binds upstream and downstream of initiating RNA polymerase, trapping it in a loop and preventing transcription . Binds to hundreds of sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome . Many of these loci were horizontally transferred (HTG); this offers the selective advantage of silencing foreign DNA while keeping it i [...] | Haemolysin expression modulating protein; Down-regulates hemolysin (hly) expression in complex with H- NS . Stimulates transposition events in vivo . Modifies the set of genes regulated by H-NS; Hha and Cnu (YdgT) increase the number of genes DNA bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex . Binds DNA and influences DNA topology in response to environmental stimuli; does not however interact with DNA in the absence of H-NS . Involved in persister cell formation, acting downstream of mRNA interferase (toxin) MqsR . Decreases biofilm formation by [...] | 0.985 |
| hns | seqA | b1237 | b0687 | A DNA-binding protein implicated in transcriptional repression (silencing) Also involved in bacterial chromosome organization and compaction . H-NS binds tightly to AT-rich dsDNA and inhibits transcription Binds upstream and downstream of initiating RNA polymerase, trapping it in a loop and preventing transcription . Binds to hundreds of sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome . Many of these loci were horizontally transferred (HTG); this offers the selective advantage of silencing foreign DNA while keeping it i [...] | Seqa, negative modulator of initiation of replication; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. Can also bind to hemimethylated GATC sequences outside of oriC region. Binds, with less affinity, to fully methylated G [...] | 0.445 |
| hns | stpA | b1237 | b2669 | A DNA-binding protein implicated in transcriptional repression (silencing) Also involved in bacterial chromosome organization and compaction . H-NS binds tightly to AT-rich dsDNA and inhibits transcription Binds upstream and downstream of initiating RNA polymerase, trapping it in a loop and preventing transcription . Binds to hundreds of sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome . Many of these loci were horizontally transferred (HTG); this offers the selective advantage of silencing foreign DNA while keeping it i [...] | Dna-binding transcriptional repressor stpa with rna chaperone activity; A DNA-binding protein that acts in a fashion similar to H-NS protein upon overexpression, represses a number of genes including the cryptic blg operon, hns, papB and the proU locus . A subset of H-NS/StpA-regulated genes also require Hha for repression; Hha and Cnu (YdgT) increases the number of genes DNA bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex . Repression can be inhibited by dominant-negative mutants of StpA or H-NS | 0.874 |
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