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STRING protein interaction network
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
protein homology
Your Input:
Gene Fusion
ygbNGluconate:h+ symporter, gntp family; Inner membrane permease YgbN; Putative transport protein (454 aa)    
Predicted Functional Partners:
Uncharacterized HTH-type transcriptional regulator YidP; Pseudogene, arbutin specific enzyme IIC component of PTS;enzyme; Transport of small molecules: Carbohydrates, organic acids, alcohols; PTS system, arbutin-like IIB component; PTS system, arbutin-like IIC component
Putative 3-oxo-tetronate 4-phosphate decarboxylase ygbl; Catalyzes the decarboxylation of 3-oxo-tetronate 4-phosphate to dihydroxyacetone phosphate (DHAP) and CO(2)
Putative 2-oxo-tetronate isomerase ygbm; Catalyzes the isomerization of 2-oxo-tetronate to 3-oxo- tetronate
Putative lysr-type transcriptional regulator yidz; Involved in anaerobic NO protection
Putative l-threonate dehydrogenase; Catalyzes oxidation of L-threonate to 2-oxo-tetronate. Can use either NAD(+) or NADP(+) as cosubstrate, with a preference for NAD(+)
Flia-regulated duf1537 family protein; Catalyzes the ATP-dependent phosphorylation of 3-oxo- tetronate to 3-oxo-tetronate 4-phosphate
D-gluconate kinase, thermostable; Belongs to the gluconokinase GntK/GntV family
D-gluconate kinase, thermosensitive; Belongs to the gluconokinase GntK/GntV family
Lps assembly om complex lptde, lipoprotein component; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
Marr family transcriptional regulator, transcriptional regulator for hemolysin; Transcription regulator that can specifically activate or repress expression of target genes. Activates expression of genes such as molecular chaperones (groL, groS, dnaK, grpE, and cbpA), proteins involved in acid resistance (hdeA, hdeB, and gadA), the starvation lipoprotein slp, virulence protein hlyE/clyA. Represses expression of genes involved in the histidine biosynthetic pathway such as hisA, hisB, hisD, hisF and hisG. Required for the activation of virulence genes
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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