STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yqjIPadr family putative transcriptional regulator; Represses the expression of YqjH which is involved in iron homeostasis under excess nickel conditions. Also represses its own expression (207 aa)    
Predicted Functional Partners:
yqjH
Nadph-dependent ferric chelate reductase; Plays a role in iron homeostasis under excess nickel conditions
  
 0.991
cynR
Lysr family transcriptional regulator, cyn operon transcriptional activator; Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR-cynTSX intergenic region
      
 0.731
murR
Rpir family transcriptional regulator, murpq operon repressor; Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6- phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator. Also represses its own transcription
  
   
 0.659
xapR
Dna-binding transcriptional activator xapr; Positive regulator required for the expression of xapA and xapB. Binds to the inducer xanthosine
      
 0.650
allS
Lysr family transcriptional regulator, transcriptional activator of the alld operon; Positive regulator essential for the expression of allD operon. Binds to the allD promoter
      
 0.641
betI
Tetr/acrr family transcriptional regulator, transcriptional repressor of bet genes; Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine
   
  
 0.611
mhpR
Iclr family transcriptional regulator, mhp operon transcriptional activator; Activator of the mhpABCDFE operon coding for components of the 3-hydroxyphenylpropionate degradation pathway
   
  
 0.605
gcvA
Lysr family transcriptional regulator, glycine cleavage system transcriptional activator; Regulatory protein for the glycine cleavage system operon (gcv). Mediates activation of gcv by glycine and repression by purines. GcvA is negatively autoregulated. Binds to three sites upstream of the gcv promoter
      
 0.520
ulaR
Deor family transcriptional regulator, ulag and ulaabcdef operon transcriptional repressor; Represses ulaG and the ulaABCDEF operon. Two ulaR binding sites have been identified in each promoter. Full activity requires simultaneous interaction of UlaR with both divergent promoters and seems to be dependent on repressor-mediated DNA loop formation, which is helped by the action of integration host factor
      
 0.520
feaR
Arac family transcriptional regulator, positive regulator of tyna and feab; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism
      
 0.519
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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