STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
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[Homology]
Score
uxaAD-altronate dehydratase; Catalyzes the dehydration of D-altronate (495 aa)    
Predicted Functional Partners:
uxaB
Altronate oxidoreductase, nad-dependent; Altronate oxidoreductase; Protein involved in carbohydrate catabolic process
 
  
 0.998
uxaC
D-glucoronate/d-galacturonate isomerase; Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family
 
  
 0.997
uxuA
D-mannonate dehydratase; Catalyzes the dehydration of D-mannonate
 
  
 0.996
kdgK
2-dehydro-3-deoxygluconokinase; Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG)
 
  
 0.990
kduD
Putative 2-keto-3-deoxy-d-gluconate dehydrogenase; Catalyzes the reversible reduction of 2,5-diketo-3- deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2-keto- 3-deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH . To a lesser extent, can also reduce 5-keto- D-gluconate and oxidize D-gluconate and 1,2-propanediol . Together with KduI, seems to play a role in the catabolism of hexuronates under osmotic stress conditions, substituting for the regular hexuronate degrading enzymes UxaABC and UxuAB whose expression is repressed in these con [...]
 
 
 0.981
exuT
Mfs transporter, acs family, hexuronate transporter; Aldohexuronate transport system
 
  
 0.945
kduI
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity). Plays a role in the catabolism of hexuronates under osmotic stress conditions, likely substituting for the regular hexuronate degrading enzyme UxaC whose expression is repressed in these conditions
 
   
 0.939
uxuB
D-mannonate oxidoreductase, nad-dependent; Belongs to the mannitol dehydrogenase family. UxuB subfamily
 
   
 0.920
exuR
Gntr family transcriptional regulator, hexuronate regulon transcriptional repressor; Repressor for the exu regulon that encode genes involved in hexuronate utilization. It regulates the ExuT, UxaCA and UxuRAB operons. Binds D-tagaturonate and D-fructuronate as inducers
 
  
 0.912
rspA
Mandelate racemase/muconate lactonizing enzyme family protein rspa; Probably involved in the degradation of homoserine lactone (HSL) or of a metabolite of HSL that signals starvation
  
 
  0.906
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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