STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yhcAPutative periplasmic chaperone protein; Could be required for the biogenesis of a putative fimbria. Belongs to the periplasmic pilus chaperone family. (224 aa)    
Predicted Functional Partners:
yhcD
Putative outer membrane fimbrial subunit usher protein; Involved in the export and assembly of a fimbrial subunit across the outer membrane; Belongs to the fimbrial export usher family.
 
  
 0.977
gltF
Periplasmic protein; Involved in induction of the so-called NTR enzymes in response to nitrogen deprivation, as well as in glutamate biosynthesis. May mediate the glutamate-dependent repression of the GLT operon.
  
  
 0.904
frvR
Putative frv operon regulator; Could be involved in the regulation of the transcription of the FRV operon.
   
  
 0.804
yhcF
Putative transcriptional regulator; Protein involved in transcription and regulation of transcription, DNA-dependent; To E.coli GltF.
  
  
 0.785
sspB
ClpXP protease specificity enhancing factor; Enhances recognition of ssrA-tagged proteins by the ClpX-ClpP protease; the ssrA degradation tag (AANDENYALAA) is added trans- translationally to proteins that are stalled on the ribosome, freeing the ribosome and targeting stalled peptides for degradation. SspB activates the ATPase activity of ClpX. Seems to act in concert with SspA in the regulation of several proteins during exponential and stationary-phase growth.
 
      0.682
yaiS
Putative PIG-L family deacetylase; Belongs to the PIGL family.
   
    0.632
yfcS
Putative periplasmic pilin chaperone; Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes.
      
 0.600
ybdO
Putative transcriptional regulator LYSR-type; Protein involved in transcription and regulation of transcription, DNA-dependent; Belongs to the LysR transcriptional regulatory family.
   
  
 0.539
chaC
Cation transport regulator; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.
      
 0.491
ybaO
Putative DNA-binding transcriptional regulator; Plays a role in L-cysteine detoxification. Binds to the dlsT(yhaO)-yhaM operon promoter in the presence but not absence of L- cysteine; activates transcription from the dlsT(yhaO)-yhaM operon. No other DNA target was identified in strain K12 / BW25113. Thiosulfate does not activate its transcription function. Overexpression doubles hydrogen sulfide production in the presence of cysteine.
      
 0.452
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.