node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aaeR | cspC | b3243 | b1823 | Transcriptional regulator for aaeXAB operon; Activates transcription of the aaeXAB operon. | Stress protein, member of the CspA-family; Cold shock protein; Protein involved in transcription activator activity, transcription and response to temperature stimulus. | 0.874 |
aaeR | helD | b3243 | b0962 | Transcriptional regulator for aaeXAB operon; Activates transcription of the aaeXAB operon. | DNA helicase IV; Helicase IV catalyzes the unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand in a reaction that is dependent upon the hydrolysis of ATP. | 0.882 |
aaeR | hypT | b3243 | b4327 | Transcriptional regulator for aaeXAB operon; Activates transcription of the aaeXAB operon. | Hypochlorite-responsive transcription factor; Protects cells from HOCl (hypochlorite) stress but not peroxide or diamide stress. Decreases the intracellular load of reactive oxygen species by up-regulating genes involved in methionine and cysteine biosynthesis and down-regulating Fur-regulated genes involved in iron acquisition. Has also been suggested to down-regulate expression of the flagellar regulon, decreasing motility, but this activity was not confirmed in a second study. Belongs to the LysR transcriptional regulatory family. | 0.912 |
aaeR | kduI | b3243 | b2843 | Transcriptional regulator for aaeXAB operon; Activates transcription of the aaeXAB operon. | Hexuronate isomerase; Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity). Plays a role in the catabolism of hexuronates under osmotic stress conditions, likely substituting for the regular hexuronate degrading enzyme UxaC whose expression is repressed in these conditions ; Belongs to the KduI family. | 0.873 |
aaeR | minE | b3243 | b1174 | Transcriptional regulator for aaeXAB operon; Activates transcription of the aaeXAB operon. | Cell division topological specificity factor; Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell. | 0.874 |
aaeR | parC | b3243 | b3019 | Transcriptional regulator for aaeXAB operon; Activates transcription of the aaeXAB operon. | DNA topoisomerase IV, subunit A; Topoisomerase IV is essential for chromosome segregation; it is the principal protein responsible for decatenating newly replicated chromosomes. It relaxes supercoiled DNA. MukB stimulates the relaxation activity of topoisomerase IV and also has a modest effect on decatenation. Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. | 0.883 |
aaeR | tufA | b3243 | b3339 | Transcriptional regulator for aaeXAB operon; Activates transcription of the aaeXAB operon. | Translation elongation factor EF-Tu 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Plays a stimulatory role in trans-translation; binds tmRNA. (Microbial infection) Upon infection by bacteriophage Qbeta, part of the viral RNA-dependent RNA polymerase complex. With EF-Ts may provide a stabilizing scaffold for the beta (catalytic) subunit. Helps separate the double-stranded RNA of the template and growing RNA during elongation. With the beta subunit helps form the exit tunnel for template RNA. (Microbial infe [...] | 0.875 |
aaeR | tufB | b3243 | b3980 | Transcriptional regulator for aaeXAB operon; Activates transcription of the aaeXAB operon. | Translation elongation factor EF-Tu 2; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Plays a stimulatory role in trans-translation, binds tmRNA. (Microbial infection) Upon infection by bacteriophage Qbeta, part of the viral RNA-dependent RNA polymerase complex. With EF-Ts may provide a stabilizing scaffold for the beta (catalytic) subunit. Helps separate the double-stranded RNA of the template and growing RNA during elongation. With the beta subunit helps form the exit tunnel for template RNA. The GTPase acti [...] | 0.893 |
aaeR | yaeQ | b3243 | b0190 | Transcriptional regulator for aaeXAB operon; Activates transcription of the aaeXAB operon. | PDDEXK superfamily protein. | 0.876 |
aaeR | yciQ | b3243 | b1268 | Transcriptional regulator for aaeXAB operon; Activates transcription of the aaeXAB operon. | Enhancer of membrane protein expression; putative inner membrane protein. | 0.874 |
cspC | aaeR | b1823 | b3243 | Stress protein, member of the CspA-family; Cold shock protein; Protein involved in transcription activator activity, transcription and response to temperature stimulus. | Transcriptional regulator for aaeXAB operon; Activates transcription of the aaeXAB operon. | 0.874 |
cspC | helD | b1823 | b0962 | Stress protein, member of the CspA-family; Cold shock protein; Protein involved in transcription activator activity, transcription and response to temperature stimulus. | DNA helicase IV; Helicase IV catalyzes the unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand in a reaction that is dependent upon the hydrolysis of ATP. | 0.731 |
cspC | hypT | b1823 | b4327 | Stress protein, member of the CspA-family; Cold shock protein; Protein involved in transcription activator activity, transcription and response to temperature stimulus. | Hypochlorite-responsive transcription factor; Protects cells from HOCl (hypochlorite) stress but not peroxide or diamide stress. Decreases the intracellular load of reactive oxygen species by up-regulating genes involved in methionine and cysteine biosynthesis and down-regulating Fur-regulated genes involved in iron acquisition. Has also been suggested to down-regulate expression of the flagellar regulon, decreasing motility, but this activity was not confirmed in a second study. Belongs to the LysR transcriptional regulatory family. | 0.420 |
cspC | kduI | b1823 | b2843 | Stress protein, member of the CspA-family; Cold shock protein; Protein involved in transcription activator activity, transcription and response to temperature stimulus. | Hexuronate isomerase; Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity). Plays a role in the catabolism of hexuronates under osmotic stress conditions, likely substituting for the regular hexuronate degrading enzyme UxaC whose expression is repressed in these conditions ; Belongs to the KduI family. | 0.874 |
cspC | minE | b1823 | b1174 | Stress protein, member of the CspA-family; Cold shock protein; Protein involved in transcription activator activity, transcription and response to temperature stimulus. | Cell division topological specificity factor; Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell. | 0.984 |
cspC | parC | b1823 | b3019 | Stress protein, member of the CspA-family; Cold shock protein; Protein involved in transcription activator activity, transcription and response to temperature stimulus. | DNA topoisomerase IV, subunit A; Topoisomerase IV is essential for chromosome segregation; it is the principal protein responsible for decatenating newly replicated chromosomes. It relaxes supercoiled DNA. MukB stimulates the relaxation activity of topoisomerase IV and also has a modest effect on decatenation. Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. | 0.984 |
cspC | tufA | b1823 | b3339 | Stress protein, member of the CspA-family; Cold shock protein; Protein involved in transcription activator activity, transcription and response to temperature stimulus. | Translation elongation factor EF-Tu 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Plays a stimulatory role in trans-translation; binds tmRNA. (Microbial infection) Upon infection by bacteriophage Qbeta, part of the viral RNA-dependent RNA polymerase complex. With EF-Ts may provide a stabilizing scaffold for the beta (catalytic) subunit. Helps separate the double-stranded RNA of the template and growing RNA during elongation. With the beta subunit helps form the exit tunnel for template RNA. (Microbial infe [...] | 0.987 |
cspC | tufB | b1823 | b3980 | Stress protein, member of the CspA-family; Cold shock protein; Protein involved in transcription activator activity, transcription and response to temperature stimulus. | Translation elongation factor EF-Tu 2; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Plays a stimulatory role in trans-translation, binds tmRNA. (Microbial infection) Upon infection by bacteriophage Qbeta, part of the viral RNA-dependent RNA polymerase complex. With EF-Ts may provide a stabilizing scaffold for the beta (catalytic) subunit. Helps separate the double-stranded RNA of the template and growing RNA during elongation. With the beta subunit helps form the exit tunnel for template RNA. The GTPase acti [...] | 0.974 |
cspC | yaeQ | b1823 | b0190 | Stress protein, member of the CspA-family; Cold shock protein; Protein involved in transcription activator activity, transcription and response to temperature stimulus. | PDDEXK superfamily protein. | 0.982 |
cspC | yciQ | b1823 | b1268 | Stress protein, member of the CspA-family; Cold shock protein; Protein involved in transcription activator activity, transcription and response to temperature stimulus. | Enhancer of membrane protein expression; putative inner membrane protein. | 0.880 |