STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yhdTDUF997 family putative inner membrane protein; To H.influenzae HI_0974B (80 aa)    
Predicted Functional Partners:
panF
Pantothenate:sodium symporter; Catalyzes the sodium-dependent uptake of extracellular pantothenate
 
  
 0.989
yijE
Eama-like transporter family protein; Involved in response to cystine. Overexpression confers tolerance to excess cystine
      
 0.878
ydhT
annotation not available
      
 0.876
prmA
Methyltransferase for 50s ribosomal subunit protein l11; Methylates ribosomal protein L11
       0.875
panM
Pand autocleavage accelerator, panothenate synthesis; Controls both the activation and catalytic activity of PanD in a coenzyme A (CoA)-dependent fashion. Binding of CoA or a derivative to PanZ leads to interaction with PanD, which promotes the processing and activation of pro-PanD, and subsequent substrate-mediated inhibition of the active form of PanD Inhibition of PanD activity is probably the primary metabolic role of PanZ, allowing negative feedback regulation of pantothenate biosynthesis by CoA
  
   
 0.779
yhdU
annotation not available
     
 0.649
accC
Acetyl-coa carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
  
    0.626
sfsB
Putative transcriptional regulator sfsb; This protein is involved in positive regulation of the metabolism of sugars
  
     0.599
accB
This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
  
    0.576
panD
Aspartate 1-decarboxylase proenzyme; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
     
 0.542
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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