node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
arsB | arsC | b3502 | b3503 | Arsenite/antimonite transporter; Involved in arsenical resistance. Thought to form the channel of an arsenite pump (By similarity); Belongs to the ArsB family. | Arsenate reductase; Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance (By similarity); Belongs to the ArsC family. | 0.979 |
arsB | arsR | b3502 | b3501 | Arsenite/antimonite transporter; Involved in arsenical resistance. Thought to form the channel of an arsenite pump (By similarity); Belongs to the ArsB family. | Arsenical resistance operon transcriptional repressor; Transcriptional repressor for the arsEFG operon. ArsE is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsE is alleviated by oxyions of +III oxidation state of arsenic, antimony, and bismuth, as well as arsenate (As(V)) (By similarity). | 0.996 |
arsB | cueR | b3502 | b0487 | Arsenite/antimonite transporter; Involved in arsenical resistance. Thought to form the channel of an arsenite pump (By similarity); Belongs to the ArsB family. | Copper-responsive regulon transcriptional regulator; Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. | 0.487 |
arsB | cusA | b3502 | b0575 | Arsenite/antimonite transporter; Involved in arsenical resistance. Thought to form the channel of an arsenite pump (By similarity); Belongs to the ArsB family. | Copper/silver efflux system, membrane component; Part of a cation efflux system that mediates resistance to copper and silver; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.555 |
arsB | cusB | b3502 | b0574 | Arsenite/antimonite transporter; Involved in arsenical resistance. Thought to form the channel of an arsenite pump (By similarity); Belongs to the ArsB family. | Copper/silver efflux system, membrane fusion protein; Part of a cation efflux system that mediates resistance to copper and silver. | 0.521 |
arsB | cusC | b3502 | b0572 | Arsenite/antimonite transporter; Involved in arsenical resistance. Thought to form the channel of an arsenite pump (By similarity); Belongs to the ArsB family. | Copper/silver efflux system, outer membrane component; Forms pores that allow passive diffusion of cations across the outer membrane. Part of a cation efflux system that mediates resistance to copper and silver. In pathogenic strains it allows the bacteria to invade brain microvascular endothelial cells (BMEC) thus allowing it to cross the blood-brain barrier and cause neonatal meningitis. | 0.529 |
arsB | cusF | b3502 | b0573 | Arsenite/antimonite transporter; Involved in arsenical resistance. Thought to form the channel of an arsenite pump (By similarity); Belongs to the ArsB family. | Periplasmic copper- and silver-binding protein; Part of a cation efflux system that mediates resistance to copper and silver. Binds one copper per polypeptide. | 0.589 |
arsB | cusR | b3502 | b0571 | Arsenite/antimonite transporter; Involved in arsenical resistance. Thought to form the channel of an arsenite pump (By similarity); Belongs to the ArsB family. | Response regulator in two-component regulatory system with CusS; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Activates the expression of cusCFBA, hiuH and plasmid pRJ1004 gene pcoE in response to increasing levels of copper or silver ions. Can also increase the basal-level expression of copper resistance gene operon pcoABCD. | 0.530 |
arsB | cusS | b3502 | b0570 | Arsenite/antimonite transporter; Involved in arsenical resistance. Thought to form the channel of an arsenite pump (By similarity); Belongs to the ArsB family. | Copper-sensing histidine kinase in two-component regulatory system with CusR; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Acts as a copper/silver ion sensor. Activates CusR by phosphorylation. | 0.600 |
arsB | sugE | b3502 | b4148 | Arsenite/antimonite transporter; Involved in arsenical resistance. Thought to form the channel of an arsenite pump (By similarity); Belongs to the ArsB family. | Multidrug efflux system protein; Guanidinium ion exporter. Couples guanidinium export to the proton motive force, exchanging one guanidinium ion for two protons. Overexpression leads to resistance to a subset of toxic quaternary ammonium compounds such as cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations. Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. Gdx/SugE subfamily. | 0.478 |
arsC | arsB | b3503 | b3502 | Arsenate reductase; Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance (By similarity); Belongs to the ArsC family. | Arsenite/antimonite transporter; Involved in arsenical resistance. Thought to form the channel of an arsenite pump (By similarity); Belongs to the ArsB family. | 0.979 |
arsC | arsR | b3503 | b3501 | Arsenate reductase; Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance (By similarity); Belongs to the ArsC family. | Arsenical resistance operon transcriptional repressor; Transcriptional repressor for the arsEFG operon. ArsE is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsE is alleviated by oxyions of +III oxidation state of arsenic, antimony, and bismuth, as well as arsenate (As(V)) (By similarity). | 0.965 |
arsC | cueR | b3503 | b0487 | Arsenate reductase; Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance (By similarity); Belongs to the ArsC family. | Copper-responsive regulon transcriptional regulator; Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. | 0.445 |
arsC | cusA | b3503 | b0575 | Arsenate reductase; Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance (By similarity); Belongs to the ArsC family. | Copper/silver efflux system, membrane component; Part of a cation efflux system that mediates resistance to copper and silver; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.526 |
arsC | cusS | b3503 | b0570 | Arsenate reductase; Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance (By similarity); Belongs to the ArsC family. | Copper-sensing histidine kinase in two-component regulatory system with CusR; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Acts as a copper/silver ion sensor. Activates CusR by phosphorylation. | 0.529 |
arsR | arsB | b3501 | b3502 | Arsenical resistance operon transcriptional repressor; Transcriptional repressor for the arsEFG operon. ArsE is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsE is alleviated by oxyions of +III oxidation state of arsenic, antimony, and bismuth, as well as arsenate (As(V)) (By similarity). | Arsenite/antimonite transporter; Involved in arsenical resistance. Thought to form the channel of an arsenite pump (By similarity); Belongs to the ArsB family. | 0.996 |
arsR | arsC | b3501 | b3503 | Arsenical resistance operon transcriptional repressor; Transcriptional repressor for the arsEFG operon. ArsE is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsE is alleviated by oxyions of +III oxidation state of arsenic, antimony, and bismuth, as well as arsenate (As(V)) (By similarity). | Arsenate reductase; Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance (By similarity); Belongs to the ArsC family. | 0.965 |
arsR | cueR | b3501 | b0487 | Arsenical resistance operon transcriptional repressor; Transcriptional repressor for the arsEFG operon. ArsE is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsE is alleviated by oxyions of +III oxidation state of arsenic, antimony, and bismuth, as well as arsenate (As(V)) (By similarity). | Copper-responsive regulon transcriptional regulator; Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. | 0.758 |
arsR | cusA | b3501 | b0575 | Arsenical resistance operon transcriptional repressor; Transcriptional repressor for the arsEFG operon. ArsE is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsE is alleviated by oxyions of +III oxidation state of arsenic, antimony, and bismuth, as well as arsenate (As(V)) (By similarity). | Copper/silver efflux system, membrane component; Part of a cation efflux system that mediates resistance to copper and silver; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.436 |
arsR | cusR | b3501 | b0571 | Arsenical resistance operon transcriptional repressor; Transcriptional repressor for the arsEFG operon. ArsE is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsE is alleviated by oxyions of +III oxidation state of arsenic, antimony, and bismuth, as well as arsenate (As(V)) (By similarity). | Response regulator in two-component regulatory system with CusS; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Activates the expression of cusCFBA, hiuH and plasmid pRJ1004 gene pcoE in response to increasing levels of copper or silver ions. Can also increase the basal-level expression of copper resistance gene operon pcoABCD. | 0.513 |