STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yiaO2,3-diketo-L-gulonate-binding periplasmic protein; Part of the tripartite ATP-independent periplasmic (TRAP) transport system YiaMNO involved in the uptake of 2,3-diketo-L- gulonate. This protein specifically binds 2,3-diketo-L-gulonate. Is not able to bind either L-ascorbate or dehydroascorbate. Belongs to the bacterial solute-binding protein 7 family. (328 aa)    
Predicted Functional Partners:
yiaM
2,3-diketo-L-gulonate TRAP transporter small permease protein; Part of the tripartite ATP-independent periplasmic (TRAP) transport system YiaMNO involved in the uptake of 2,3-diketo-L- gulonate.
 
 
 0.999
yiaN
2,3-diketo-L-gulonate TRAP transporter large permease protein; Part of the tripartite ATP-independent periplasmic (TRAP) transport system YiaMNO involved in the uptake of 2,3-diketo-L- gulonate.
 
 0.999
sgbU
Putative L-xylulose 5-phosphate 3-epimerase; Catalyzes the isomerization of L-xylulose-5-phosphate to L- ribulose-5-phosphate (Potential). May be involved in the utilization of 2,3-diketo-L-gulonate; Belongs to the L-ribulose-5-phosphate 3-epimerase family.
  
  
 0.928
yiaK
2,3-diketo-L-gulonate reductase, NADH-dependent; Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate.
 
  
 0.922
lyxK
L-xylulose kinase; Catalyzes the phosphorylation of L-xylulose and 3-keto-L- gulonate. Is involved in L-lyxose utilization via xylulose, and may also be involved in the utilization of 2,3-diketo-L-gulonate.
  
  
 0.919
sgbH
3-keto-L-gulonate 6-phosphate decarboxylase; Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. May be involved in the utilization of 2,3-diketo-L- gulonate.
  
  
 0.901
sgbE
L-ribulose-5-phosphate 4-epimerase; Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D-xylulose 5-phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon-carbon bond cleavage analogous to a class II aldolase reaction). May be involved in the utilization of 2,3-diketo-L-gulonate.
  
  
 0.891
yiaL
DUF386 family protein; Putative lipase; Belongs to the TabA/YhcH/YiaL family.
  
  
 0.840
yehI
Uncharacterized protein YehI; DUF4132 family pseudogene; defective yehI paralog; molybdate metabolism regulator, first fragment; molybdate metabolism regulator, second fragment 2; yehI' molR mutations have phenotypes and the N-terminal molR fragment of yehI' may be expressed and may have retained or evolved MolR function.
      
 0.804
yjcE
Putative cation/proton antiporter.
   
  
 0.733
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.