STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
yieHPhosphoenolpyruvate and 6-phosphogluconate phosphatase; Catalyzes strongly the dephosphorylation of 6- phosphogluconate (6P-Glu) and slightly the dephosphorylation of dihydroxyacetone phosphate (DHAP) and phosphoenolpyruvate (PEP). Also hydrolyzes both purines (GMP and IMP) and pyrimidines as secondary substrates. (221 aa)    
Predicted Functional Partners:
yrfG
GMP/IMP nucleotidase; Catalyzes the dephosphorylation of different purine nucleotides (GMP and IMP). Also hydrolyzes flavin mononucleotide (FMN). Belongs to the HAD-like hydrolase superfamily.
   
 
 0.829
yjjG
dUMP phosphatase; Nucleotidase that shows high phosphatase activity toward non- canonical pyrimidine nucleotides and three canonical nucleoside 5'- monophosphates (UMP, dUMP, and dTMP), and very low activity against TDP, IMP, UDP, GMP, dGMP, AMP, dAMP, and 6-phosphogluconate. Appears to function as a house-cleaning nucleotidase in vivo, since the general nucleotidase activity of YjjG allows it to protect cells against non- canonical pyrimidine derivatives such as 5-fluoro-2'-deoxyuridine, 5- fluorouridine, 5-fluoroorotate, 5-fluorouracil, and 5-aza-2'- deoxycytidine, and prevents the i [...]
   
 
 0.815
cbrB
PRK09823 family inner membrane protein, creBC regulon.
  
  
 0.759
yqaB
fructose-1-P and 6-phosphogluconate phosphatase; Catalyzes strongly the dephosphorylation of fructose-1- phosphate (Fru1P) and slightly the dephosphorylation of 6- phosphogluconate (6P-Glu). It has low beta-phosphoglucomutase activity.
  
     0.757
yniC
2-deoxyglucose-6-P phosphatase; Sugar-phosphate phosphohydrolase that catalyzes the dephosphorylation of D-mannitol 1-phosphate and D-sorbitol 6-phosphate. Also catalyzes the dephosphorylation of 2- deoxyglucose 6-phosphate (2dGlu6P); this is a biologically important activity in vivo since it contributes to the elimination of this toxic compound and plays an important role in the resistance of E.coli to 2- deoxyglucose. To a lesser extent, is also able to dephosphorylate mannose 6-phosphate (Man6P), erythrose-4-phosphate, 2- deoxyribose-5-phosphate (2dRib5P), ribose-5-phosphate (Rib5P) [...]
  
     0.725
ycjU
Beta-phosphoglucomutase; Catalyzes the conversion of beta D-glucose 1-phosphate (G1P) to D-glucose 6-phosphate (G6P), forming beta-D-glucose 1,6- (bis)phosphate (beta-G16P) as an intermediate (Probable). Phosphatase activity with the reaction intermediate beta-G16P has been measured. In vitro interconverts beta D-glucose 1-phosphate, beta-D-allose 1-phosphate, beta-D-galactose 1-phosphate and beta-D-mannose 1-phosphate to their corresponding sugar 6-phosphate product. The beta-D-glucose 1-phosphate substrate may be furnished by YcjT (AC P77154), the apparent upstream enzyme in the put [...]
  
     0.703
cbrC
UPF0167 family protein; Belongs to the UPF0167 family.
  
  
 0.664
yphH
Putative NAGC-like transcriptional regulator; Protein involved in regulation of transcription, DNA-dependent; Belongs to the ROK (NagC/XylR) family.
      
 0.642
ogrK
Orphan Ogr protein, positive regulator of P2 growth; Cryptic version of the phage P2 OGR protein which acts as an activator of P2 late transcription.
      
 0.619
adeP
Adenine permease, high affinity; High-affinity transporter for adenine. Belongs to the xanthine/uracil permease family. AzgA purine transporter (TC 2.A.1.40) subfamily.
  
    0.615
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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