STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cysQ3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. May also convert adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS). Has 10000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2); Belongs to the inositol monophosphatase superfamily. CysQ family. (246 aa)    
Predicted Functional Partners:
cysC
Adenosine 5'-phosphosulfate kinase; Catalyzes the synthesis of activated sulfate.
 
 0.999
cysD
ATP:sulfurylase (ATP:sulfate adenylyltransferase), subunit 2; Protein involved in sulfur metabolic process; Belongs to the PAPS reductase family. CysD subfamily.
 
 0.985
cysH
Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite.
  
 
 0.985
cysN
Sulfate adenylyltransferase, subunit 1; May be the GTPase, regulating ATP sulfurylase activity.
 
 
 0.973
argK
Membrane ATPase/protein kinase; Binds and hydrolyzes GTP. Likely functions as a G-protein chaperone that assists AdoCbl cofactor delivery to the methylmalonyl-CoA mutase (MCM) ScpA and reactivation of the enzyme during catalysis; Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.
      
 0.878
orn
Oligoribonuclease; 3'-to-5' exoribonuclease specific for small oligoribonucleotides 2 to 5 nucleotides in length, as well as small (2 to 5 nucleotides) ssDNA oligomers. Probably responsible for the final step in mRNA degradation.
      
 0.858
pheM
phenylalanyl-tRNA synthetase (pheST) operon leader peptide; Protein involved in tRNA aminoacylation for protein translation.
      
 0.785
cpdB
2':3'-cyclic-nucleotide 2'-phosphodiesterase; This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2',3'-cyclic nucleotide to a 3'-nucleotide and then the 3'-nucleotide to the corresponding nucleoside and phosphate; Belongs to the 5'-nucleotidase family.
     
 0.683
sufC
SufBCD Fe-S cluster assembly scaffold protein, ATP-binding protein; Has low ATPase activity. The SufBCD complex acts synergistically with SufE to stimulate the cysteine desulfurase activity of SufS. The SufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation.
 
 
    0.681
uspB
Protein involved in response to stress and xenobiotic metabolic process.
   
    0.645
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.