STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hyfJPutative processing element hydrogenase 4; Possible component of hydrogenase 4. (137 aa)    
Predicted Functional Partners:
hyfR
Hydrogenase-4 transcriptional activator; A transcriptional activator of its own operon; when overexpressed operon expression is strongly enhanced by low pH (under pH 6.0), strongly inhibited by O(2) but only weakly stimulated by fumarate. Expression in situ is very weak.
  
  
 0.940
yfgI
Nalidixic acid resistance protein, putative periplasmic protein; Putative membrane protein.
      
 0.878
hyfA
Hydrogenase 4, 4Fe-4S subunit; Probable electron transfer protein for hydrogenase 4.
  
  
 0.824
hyfI
Hydrogenase 4, Fe-S subunit; Possible component of hydrogenase 4. Belongs to the complex I 20 kDa subunit family.
 
    0.808
hyfG
Hydrogenase 4, subunit; Possible component of hydrogenase 4.
  
    0.807
yncH
IPR020099 family protein.
      
 0.801
ycgY
Uncharacterized protein.
      
 0.800
hyfF
Hydrogenase 4, membrane subunit; Possible component of hydrogenase 4. Belongs to the complex I subunit 5 family.
  
  
 0.794
hyfH
Hydrogenase 4, Fe-S subunit; Probable electron transfer protein for hydrogenase 4.
  
    0.788
hyfE
Hydrogenase 4, membrane subunit; Possible component of hydrogenase 4.
  
  
 0.783
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.