Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (361 aa)    
Predicted Functional Partners:
CFPG_590
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 0.999
leuD
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
 
 0.995
CFPG_606
Acetolactate synthase small subunit.
  
 0.980
CFPG_605
Acetolactate synthase large subunit.
 
 0.965
CFPG_567
Shikimate 5-dehydrogenase.
   
 
 0.823
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family.
  
  
 0.803
nuoD
NADH dehydrogenase I subunit CD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the C-terminal section; belongs to the complex I 49 kDa subunit family.
  
 0.730
CFPG_305
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate.
  
 0.695
CFPG_657
Homoserine dehydrogenase/aspartate kinase.
  
  
 0.690
CFPG_473
Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 
 0.678
Your Current Organism:
Azobacteroides pseudotrichonymphae
NCBI taxonomy Id: 511995
Other names: C. Azobacteroides pseudotrichonymphae genomovar. CFP2, Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2
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