STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KYG_07266COG2873 O-acetylhomoserine sulfhydrylase. (427 aa)    
Predicted Functional Partners:
metX
Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
 
 
 0.972
KYG_03131
Cys/Met metabolism pyridoxal-phosphate-dependent enzyme; COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases.
 
 
0.939
KYG_04944
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.920
KYG_09210
COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain.
  
 
 0.919
ahcY
S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
     
 0.915
KYG_18306
COG0460 Homoserine dehydrogenase.
  
 
 0.887
KYG_05159
COG0031 Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.
  
 
 0.874
KYG_18596
Pyridoxal-5'-phosphate-dependent enzyme subunit beta; COG0031 Cysteine synthase.
  
 
 0.874
KYG_08715
Hypothetical protein; COG1171 Threonine dehydratase.
   
 
  0.870
KYG_09300
Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
   
 
  0.870
Your Current Organism:
Nocardioides sp. SLBN35
NCBI taxonomy Id: 512030
Other names: Acidovorax sp. NO1, N. sp. SLBN-35, Nocardioides sp. SLBN-35
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