node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KYG_09480 | KYG_10840 | KYG_09480 | KYG_10840 | COG0427 Acetyl-CoA hydrolase. | COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. | 0.975 |
KYG_09480 | KYG_11165 | KYG_09480 | KYG_11165 | COG0427 Acetyl-CoA hydrolase. | COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit. | 0.961 |
KYG_09480 | KYG_11170 | KYG_09480 | KYG_11170 | COG0427 Acetyl-CoA hydrolase. | COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit. | 0.961 |
KYG_09480 | KYG_16952 | KYG_09480 | KYG_16952 | COG0427 Acetyl-CoA hydrolase. | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.927 |
KYG_09480 | KYG_16957 | KYG_09480 | KYG_16957 | COG0427 Acetyl-CoA hydrolase. | COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | 0.927 |
KYG_09480 | KYG_21599 | KYG_09480 | KYG_21599 | COG0427 Acetyl-CoA hydrolase. | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.920 |
KYG_09480 | acsA | KYG_09480 | KYG_17737 | COG0427 Acetyl-CoA hydrolase. | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.932 |
KYG_09480 | glcB | KYG_09480 | KYG_00552 | COG0427 Acetyl-CoA hydrolase. | Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | 0.933 |
KYG_09480 | sucC | KYG_09480 | KYG_05494 | COG0427 Acetyl-CoA hydrolase. | succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.959 |
KYG_09480 | sucD | KYG_09480 | KYG_05499 | COG0427 Acetyl-CoA hydrolase. | succinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.954 |
KYG_10840 | KYG_09480 | KYG_10840 | KYG_09480 | COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. | COG0427 Acetyl-CoA hydrolase. | 0.975 |
KYG_10840 | KYG_11165 | KYG_10840 | KYG_11165 | COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. | COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit. | 0.986 |
KYG_10840 | KYG_11170 | KYG_10840 | KYG_11170 | COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. | COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit. | 0.986 |
KYG_10840 | KYG_16952 | KYG_10840 | KYG_16952 | COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.414 |
KYG_10840 | KYG_16957 | KYG_10840 | KYG_16957 | COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. | COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | 0.864 |
KYG_10840 | KYG_21599 | KYG_10840 | KYG_21599 | COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.855 |
KYG_10840 | glcB | KYG_10840 | KYG_00552 | COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. | Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | 0.412 |
KYG_10840 | sucC | KYG_10840 | KYG_05494 | COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. | succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.955 |
KYG_10840 | sucD | KYG_10840 | KYG_05499 | COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. | succinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.954 |
KYG_11165 | KYG_09480 | KYG_11165 | KYG_09480 | COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit. | COG0427 Acetyl-CoA hydrolase. | 0.961 |