node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KYG_06024 | KYG_10440 | KYG_06024 | KYG_10440 | COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.449 |
KYG_06024 | KYG_10625 | KYG_06024 | KYG_10625 | COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. | Heat shock protein DnaJ domain-containing protein; COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. | 0.739 |
KYG_06024 | KYG_11619 | KYG_06024 | KYG_11619 | COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. | Type 12 methyltransferase; COG0457 FOG: TPR repeat. | 0.858 |
KYG_06024 | groEL | KYG_06024 | KYG_14788 | COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.967 |
KYG_06024 | grpE | KYG_06024 | KYG_06009 | COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.987 |
KYG_06024 | hscA | KYG_06024 | KYG_10455 | COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. | Chaperone protein HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. | 0.997 |
KYG_06024 | htpG | KYG_06024 | KYG_12986 | COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. | Heat shock protein 90; Molecular chaperone. Has ATPase activity. | 0.995 |
KYG_10440 | KYG_06024 | KYG_10440 | KYG_06024 | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. | 0.449 |
KYG_10440 | KYG_10460 | KYG_10440 | KYG_10460 | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | Ferredoxin, 2Fe-2S type, ISC system; COG0633 Ferredoxin. | 0.995 |
KYG_10440 | KYG_10625 | KYG_10440 | KYG_10625 | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | Heat shock protein DnaJ domain-containing protein; COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. | 0.425 |
KYG_10440 | hscA | KYG_10440 | KYG_10455 | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | Chaperone protein HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. | 0.977 |
KYG_10440 | hscB | KYG_10440 | KYG_10450 | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | Co-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.998 |
KYG_10460 | KYG_10440 | KYG_10460 | KYG_10440 | Ferredoxin, 2Fe-2S type, ISC system; COG0633 Ferredoxin. | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.995 |
KYG_10460 | hscA | KYG_10460 | KYG_10455 | Ferredoxin, 2Fe-2S type, ISC system; COG0633 Ferredoxin. | Chaperone protein HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. | 0.975 |
KYG_10460 | hscB | KYG_10460 | KYG_10450 | Ferredoxin, 2Fe-2S type, ISC system; COG0633 Ferredoxin. | Co-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.991 |
KYG_10625 | KYG_06024 | KYG_10625 | KYG_06024 | Heat shock protein DnaJ domain-containing protein; COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. | COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. | 0.739 |
KYG_10625 | KYG_10440 | KYG_10625 | KYG_10440 | Heat shock protein DnaJ domain-containing protein; COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.425 |
KYG_10625 | KYG_11619 | KYG_10625 | KYG_11619 | Heat shock protein DnaJ domain-containing protein; COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. | Type 12 methyltransferase; COG0457 FOG: TPR repeat. | 0.858 |
KYG_10625 | groEL | KYG_10625 | KYG_14788 | Heat shock protein DnaJ domain-containing protein; COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.917 |
KYG_10625 | grpE | KYG_10625 | KYG_06009 | Heat shock protein DnaJ domain-containing protein; COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.957 |