STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (430 aa)    
Predicted Functional Partners:
carA
Carbamoyl phosphate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarA family.
  
 0.999
pyrB
Aspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 0.999
carB
Carbamoyl phosphate synthase large subunit; Four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.998
pyrR
Uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
 
 
 0.998
pyrD
Diguanylate cyclase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
  
 0.996
pyrF
Orotidine 5'-phosphate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the OMP decarboxylase family. Type 2 subfamily.
 
  
 0.983
KLO31070.1
Transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.977
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
 
 
 0.943
KLO27431.1
2-polyprenylphenol hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the globin family.
  
 
 0.908
KLO27437.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.870
Your Current Organism:
Mycolicibacter heraklionensis
NCBI taxonomy Id: 512402
Other names: CECT 7509, LMG 24735, LMG:24735, M. heraklionensis, Mycobacterium heraklionense, Mycobacterium heraklionense Tortoli et al. 2013, Mycobacterium sp. FI-05158, Mycobacterium sp. FI-06009, Mycobacterium sp. FI-06082, Mycobacterium sp. FI-06150, Mycobacterium sp. FI-06255, Mycobacterium sp. FI-09376, Mycobacterium sp. GN-1, Mycobacterium sp. NCTC 13432, Mycolicibacter heraklionensis (Tortoli et al. 2013) Gupta et al. 2018, NCTC 13432, strain GN-1
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