STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (180 aa)    
Predicted Functional Partners:
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
 0.996
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
  
 
 0.973
KLO30373.1
Adenylosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 0.971
KLO29633.1
Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
  
 
 0.969
KLO28121.1
Hypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
   
 0.963
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase; Involved in de novo purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.960
KLO26191.1
Ribokinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.959
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
  
 
 0.945
KLO25982.1
Nucleoside hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.924
secD
Preprotein translocase subunit SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
  
    0.918
Your Current Organism:
Mycolicibacter heraklionensis
NCBI taxonomy Id: 512402
Other names: CECT 7509, LMG 24735, LMG:24735, M. heraklionensis, Mycobacterium heraklionense, Mycobacterium heraklionense Tortoli et al. 2013, Mycobacterium sp. FI-05158, Mycobacterium sp. FI-06009, Mycobacterium sp. FI-06082, Mycobacterium sp. FI-06150, Mycobacterium sp. FI-06255, Mycobacterium sp. FI-09376, Mycobacterium sp. GN-1, Mycobacterium sp. NCTC 13432, Mycolicibacter heraklionensis (Tortoli et al. 2013) Gupta et al. 2018, NCTC 13432, strain GN-1
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