STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KLO25543.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (468 aa)    
Predicted Functional Partners:
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
       0.832
ribBA
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
    
  0.668
KLO25541.1
Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.561
KLO31134.1
Adenylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
     
 0.536
KLO25540.1
Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family.
       0.534
glnE
Bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...]
       0.525
KLO25427.1
Transcriptional regulator, ArsR family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.496
KLO29981.1
TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.471
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
    
  0.451
KLO25583.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.410
Your Current Organism:
Mycolicibacter heraklionensis
NCBI taxonomy Id: 512402
Other names: CECT 7509, LMG 24735, LMG:24735, M. heraklionensis, Mycobacterium heraklionense, Mycobacterium heraklionense Tortoli et al. 2013, Mycobacterium sp. FI-05158, Mycobacterium sp. FI-06009, Mycobacterium sp. FI-06082, Mycobacterium sp. FI-06150, Mycobacterium sp. FI-06255, Mycobacterium sp. FI-09376, Mycobacterium sp. GN-1, Mycobacterium sp. NCTC 13432, Mycolicibacter heraklionensis (Tortoli et al. 2013) Gupta et al. 2018, NCTC 13432, strain GN-1
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