STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
AMIS_38380Putative citrate synthase; Belongs to the citrate synthase family. (375 aa)    
Predicted Functional Partners:
AMIS_16520
Putative aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
 
 0.992
mdh
Putative lactate/malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
  
 0.983
AMIS_25560
Putative acetyl-CoA synthetase.
  
 0.949
acsA
Putative acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 0.949
AMIS_77390
Putative fumarate hydratase class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
 
 0.949
AMIS_33690
Putative branched-chain alpha-keto acid dehydrogenase E2 subunit.
  
 0.946
AMIS_760
Putative dihydrolipoamide acyltransferase component.
  
 0.946
AMIS_52600
Putative malate synthase; Belongs to the malate synthase family.
   
 0.940
AMIS_63770
Putative malate synthase.
   
 0.940
AMIS_75710
Putative 2-oxoglutarate ferredoxin oxidoreductase alpha subunit.
  
 
 0.938
Your Current Organism:
Actinoplanes missouriensis
NCBI taxonomy Id: 512565
Other names: A. missouriensis 431, Actinoplanes missouriensis 431, Actinoplanes missouriensis str. 431, Actinoplanes missouriensis strain 431
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