Herpud1 protein (Jaculus jaculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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Coexpression

Experiments

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[Homology]

Score

Herpud1

Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1. (374 aa)

Predicted Functional Partners:

Syvn1

0.867

ENSJJAP00000014970

0.862

Sel1l

0.548

Zfp622

0.537

Dnajb9

0.537

ENSJJAP00000003791

0.530

ENSJJAP00000004650

0.530

ENSJJAP00000011971

0.530

Manf

0.524

Uba6

0.497

Your Current Organism:

Jaculus jaculus

NCBI taxonomy Id: 51337
Other names: J. jaculus, lesser Egyptian jerboa

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Dnajb9	Herpud1	ENSJJAP00000004881	ENSJJAP00000010845	DnaJ heat shock protein family (Hsp40) member B9.	Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1.	0.537
Dnajb9	Manf	ENSJJAP00000004881	ENSJJAP00000016302	DnaJ heat shock protein family (Hsp40) member B9.	Mesencephalic astrocyte-derived neurotrophic factor.	0.567
ENSJJAP00000003791	Herpud1	ENSJJAP00000003791	ENSJJAP00000010845	annotation not available	Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1.	0.530
ENSJJAP00000004650	Herpud1	ENSJJAP00000004650	ENSJJAP00000010845	annotation not available	Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1.	0.530
ENSJJAP00000011971	Herpud1	ENSJJAP00000011971	ENSJJAP00000010845	annotation not available	Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1.	0.530
ENSJJAP00000014970	Herpud1	ENSJJAP00000014970	ENSJJAP00000010845	annotation not available	Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1.	0.862
ENSJJAP00000014970	Sel1l	ENSJJAP00000014970	ENSJJAP00000006530	annotation not available	Sel-1 suppressor of lin-12-like (C. elegans).	0.981
ENSJJAP00000014970	Syvn1	ENSJJAP00000014970	ENSJJAP00000006606	annotation not available	Synovial apoptosis inhibitor 1, synoviolin.	0.470
Herpud1	Dnajb9	ENSJJAP00000010845	ENSJJAP00000004881	Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1.	DnaJ heat shock protein family (Hsp40) member B9.	0.537
Herpud1	ENSJJAP00000003791	ENSJJAP00000010845	ENSJJAP00000003791	Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1.	annotation not available	0.530
Herpud1	ENSJJAP00000004650	ENSJJAP00000010845	ENSJJAP00000004650	Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1.	annotation not available	0.530
Herpud1	ENSJJAP00000011971	ENSJJAP00000010845	ENSJJAP00000011971	Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1.	annotation not available	0.530
Herpud1	ENSJJAP00000014970	ENSJJAP00000010845	ENSJJAP00000014970	Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1.	annotation not available	0.862
Herpud1	Manf	ENSJJAP00000010845	ENSJJAP00000016302	Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1.	Mesencephalic astrocyte-derived neurotrophic factor.	0.524
Herpud1	Sel1l	ENSJJAP00000010845	ENSJJAP00000006530	Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1.	Sel-1 suppressor of lin-12-like (C. elegans).	0.548
Herpud1	Syvn1	ENSJJAP00000010845	ENSJJAP00000006606	Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1.	Synovial apoptosis inhibitor 1, synoviolin.	0.867
Herpud1	Uba6	ENSJJAP00000010845	ENSJJAP00000022980	Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1.	Ubiquitin-like modifier activating enzyme 6.	0.497
Herpud1	Zfp622	ENSJJAP00000010845	ENSJJAP00000001070	Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1.	Zinc finger protein 622.	0.537
Manf	Dnajb9	ENSJJAP00000016302	ENSJJAP00000004881	Mesencephalic astrocyte-derived neurotrophic factor.	DnaJ heat shock protein family (Hsp40) member B9.	0.567
Manf	Herpud1	ENSJJAP00000016302	ENSJJAP00000010845	Mesencephalic astrocyte-derived neurotrophic factor.	Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1.	0.524

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Network Stats

number of nodes:

11

number of edges:

18

average node degree:

3.27

avg. local clustering coefficient:

0.895

expected number of edges:

13

PPI enrichment p-value:

0.085

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006006

Glucose metabolic process

3 of 10

1.96

1.4

0.0017

GO:0005996

Monosaccharide metabolic process

4 of 29

1.62

1.3

0.0014

GO:0006090

Pyruvate metabolic process

3 of 15

1.78

1.18

0.0040

GO:0006091

Generation of precursor metabolites and energy

5 of 77

1.29

1.08

0.0014

GO:0006098

Pentose-phosphate shunt

2 of 3

2.3

1.06

0.0111

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016861

Intramolecular oxidoreductase activity, interconverting aldoses and ketoses

3 of 12

1.88

1.09

0.0073

GO:0016903

Oxidoreductase activity, acting on the aldehyde or oxo group of donors

3 of 22

1.61

0.93

0.0121

GO:0016853

Isomerase activity

4 of 75

1.21

0.76

0.0131

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:622

Pentose phosphate pathway, and Glyceraldehyde-3-phosphate dehydrogenase, type I

8 of 20

2.08

5.04

1.05e-12

CL:649

Pentose phosphate pathway

4 of 6

2.3

2.94

1.73e-06

CL:426

Mixed, incl. Carbon metabolism, and Fatty acid metabolism

11 of 148

1.35

2.43

1.05e-12

CL:623

Glycolysis, and Glyceraldehyde-3-phosphate dehydrogenase, type I

4 of 13

1.97

2.28

1.66e-05

CL:626

Glycolysis

2 of 6

2.0

0.84

0.0264

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00030

Pentose phosphate pathway

7 of 22

1.98

4.31

3.12e-11

map01200

Carbon metabolism

11 of 86

1.59

3.68

8.75e-16

map00010

Glycolysis / Gluconeogenesis

5 of 42

1.55

2.02

3.91e-06

map01230

Biosynthesis of amino acids

8 of 130

1.27

1.81

2.55e-08

map01120

Microbial metabolism in diverse environments

11 of 248

1.13

1.64

3.12e-11

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0312

Gluconeogenesis

2 of 4

2.18

0.99

0.0145

KW-0413

Isomerase

4 of 59

1.31

0.9

0.0069

KW-0324

Glycolysis

2 of 9

1.83

0.76

0.0352

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF17147

Pyruvate:ferredoxin oxidoreductase core domain II

2 of 2

2.48

0.84

0.0300

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029061

Thiamin diphosphate-binding fold

4 of 11

2.04

1.98

0.00011

IPR009014

Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II

3 of 7

2.11

1.41

0.0020

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00861

Transketolase, pyrimidine binding domain

2 of 6

2.0

0.82

0.0281

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