Itga8 protein (Jaculus jaculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

Itga8

Integrin alpha 8. (1049 aa)

Predicted Functional Partners:

Itgb3

0.989

Fn1

0.968

ENSJJAP00000009015

0.957

Itgb8

0.947

Itgb6

0.947

Npnt

0.946

Vtn

0.933

Flnb

0.930

Itgb5

0.923

Flna

0.918

Your Current Organism:

Jaculus jaculus

NCBI taxonomy Id: 51337
Other names: J. jaculus, lesser Egyptian jerboa

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structured XML interaction data, according to the 'PSI-MI' data standard

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSJJAP00000009015	Flna	ENSJJAP00000009015	ENSJJAP00000012505	annotation not available	Filamin, alpha.	0.984
ENSJJAP00000009015	Flnb	ENSJJAP00000009015	ENSJJAP00000017882	annotation not available	Filamin, beta.	0.968
ENSJJAP00000009015	Fn1	ENSJJAP00000009015	ENSJJAP00000020516	annotation not available	Fibronectin 1.	0.997
ENSJJAP00000009015	Itga8	ENSJJAP00000009015	ENSJJAP00000014510	annotation not available	Integrin alpha 8.	0.957
ENSJJAP00000009015	Itgb3	ENSJJAP00000009015	ENSJJAP00000015285	annotation not available	Integrin beta 3.	0.892
ENSJJAP00000009015	Itgb5	ENSJJAP00000009015	ENSJJAP00000003452	annotation not available	Integrin beta 5.	0.951
ENSJJAP00000009015	Itgb6	ENSJJAP00000009015	ENSJJAP00000008393	annotation not available	Integrin beta 6.	0.796
ENSJJAP00000009015	Itgb8	ENSJJAP00000009015	ENSJJAP00000005330	annotation not available	Integrin beta 8.	0.772
ENSJJAP00000009015	Npnt	ENSJJAP00000009015	ENSJJAP00000003784	annotation not available	Nephronectin.	0.894
ENSJJAP00000009015	Vtn	ENSJJAP00000009015	ENSJJAP00000016523	annotation not available	Vitronectin.	0.942
Flna	ENSJJAP00000009015	ENSJJAP00000012505	ENSJJAP00000009015	Filamin, alpha.	annotation not available	0.984
Flna	Flnb	ENSJJAP00000012505	ENSJJAP00000017882	Filamin, alpha.	Filamin, beta.	0.921
Flna	Fn1	ENSJJAP00000012505	ENSJJAP00000020516	Filamin, alpha.	Fibronectin 1.	0.459
Flna	Itga8	ENSJJAP00000012505	ENSJJAP00000014510	Filamin, alpha.	Integrin alpha 8.	0.918
Flna	Itgb3	ENSJJAP00000012505	ENSJJAP00000015285	Filamin, alpha.	Integrin beta 3.	0.997
Flna	Itgb5	ENSJJAP00000012505	ENSJJAP00000003452	Filamin, alpha.	Integrin beta 5.	0.969
Flna	Itgb6	ENSJJAP00000012505	ENSJJAP00000008393	Filamin, alpha.	Integrin beta 6.	0.962
Flna	Itgb8	ENSJJAP00000012505	ENSJJAP00000005330	Filamin, alpha.	Integrin beta 8.	0.959
Flnb	ENSJJAP00000009015	ENSJJAP00000017882	ENSJJAP00000009015	Filamin, beta.	annotation not available	0.968
Flnb	Flna	ENSJJAP00000017882	ENSJJAP00000012505	Filamin, beta.	Filamin, alpha.	0.921

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

13

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006457

Protein folding

9 of 181

1.98

4.96

1.46e-13

GO:0070202

Regulation of establishment of protein localization to chromosome

3 of 7

2.91

2.35

5.16e-05

GO:0051131

Chaperone-mediated protein complex assembly

3 of 14

2.61

2.02

0.00019

GO:0032212

Positive regulation of telomere maintenance via telomerase

3 of 15

2.58

2.01

0.00019

GO:1901998

Toxin transport

3 of 25

2.36

1.8

0.00042

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140662

ATP-dependent protein folding chaperone

8 of 32

2.68

8.25

3.58e-17

GO:0051082

Unfolded protein binding

9 of 99

2.24

6.82

1.30e-16

GO:0016887

ATP hydrolysis activity

8 of 313

1.69

3.24

2.88e-10

GO:0005524

ATP binding

10 of 1707

1.05

1.29

5.87e-08

GO:0005515

Protein binding

10 of 6721

0.45

0.34

0.0091

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005832

Chaperonin-containing T-complex

7 of 8

3.22

9.25

7.43e-18

GO:0005829

Cytosol

8 of 2661

0.76

0.57

0.0032

GO:0015630

Microtubule cytoskeleton

5 of 1109

0.93

0.49

0.0460

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:16454

TCP-1/cpn60 chaperonin family, and Protein FAM161A/B

11 of 13

3.21

15.74

1.24e-30

CL:16457

Chaperonin TCP-1, conserved site

8 of 8

3.28

11.24

1.41e-21

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03018

RNA degradation

10 of 146

2.12

6.95

8.11e-19

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-390471

Association of TriC/CCT with target proteins during biosynthesis

9 of 19

2.96

11.15

2.88e-22

MAP-6814122

Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

9 of 61

2.45

8.26

1.35e-18

MAP-390466

Chaperonin-mediated protein folding

9 of 75

2.36

7.74

5.09e-18

MAP-391251

Protein folding

9 of 80

2.33

7.6

6.58e-18

MAP-5620922

BBSome-mediated cargo-targeting to cilium

2 of 17

2.35

1.05

0.0118

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005832

Chaperonin-containing T-complex

8 of 9

3.23

10.84

6.50e-21

GOCC:0032991

Protein-containing complex

9 of 4409

0.59

0.41

0.0110

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0143

Chaperone

8 of 23

2.82

9.39

4.42e-19

KW-0963

Cytoplasm

7 of 292

1.66

2.9

5.55e-09

KW-0067

ATP-binding

8 of 888

1.24

1.65

1.67e-07

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00118

TCP-1/cpn60 chaperonin family

10 of 13

3.17

13.82

6.25e-27

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR027413

GroEL-like equatorial domain superfamily

9 of 11

3.19

12.01

2.85e-23

IPR027409

GroEL-like apical domain superfamily

9 of 12

3.16

11.97

2.85e-23

IPR002423

Chaperonin Cpn60/GroEL/TCP-1 family

9 of 12

3.16

11.97

2.85e-23

IPR017998

Chaperone tailless complex polypeptide 1 (TCP-1)

8 of 8

3.28

11.01

3.83e-21

IPR027410

TCP-1-like chaperonin intermediate domain superfamily

8 of 9

3.23

10.87

5.78e-21

(more ...)

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