Alk protein (Castor canadensis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

Alk

ALK tyrosine kinase receptor. (1210 aa)

Predicted Functional Partners:

Eml4

0.982

Pik3ca

0.966

Plcg1

0.952

Pik3r1

0.951

Plcg2

0.943

Pik3cd

0.941

Jak1

0.938

Pik3r3

0.937

Jak2

0.937

Hras

0.932

Your Current Organism:

Castor canadensis

NCBI taxonomy Id: 51338
Other names: American beaver, C. canadensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Alk	Eml4	ENSCCNP00000002014	ENSCCNP00000007986	ALK tyrosine kinase receptor.	Echinoderm microtubule-associated protein-like 4 isoform X1.	0.982
Alk	Hras	ENSCCNP00000002014	ENSCCNP00000010500	ALK tyrosine kinase receptor.	GTPase HRas isoform X1.	0.932
Alk	Jak1	ENSCCNP00000002014	ENSCCNP00000014861	ALK tyrosine kinase receptor.	Tyrosine-protein kinase JAK1 isoform X1.	0.938
Alk	Jak2	ENSCCNP00000002014	ENSCCNP00000013119	ALK tyrosine kinase receptor.	Tyrosine-protein kinase JAK2 isoform X1.	0.937
Alk	Pik3ca	ENSCCNP00000002014	ENSCCNP00000031019	ALK tyrosine kinase receptor.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1.	0.966
Alk	Pik3cd	ENSCCNP00000002014	ENSCCNP00000030856	ALK tyrosine kinase receptor.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1.	0.941
Alk	Pik3r1	ENSCCNP00000002014	ENSCCNP00000019333	ALK tyrosine kinase receptor.	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.	0.951
Alk	Pik3r3	ENSCCNP00000002014	ENSCCNP00000002499	ALK tyrosine kinase receptor.	Phosphoinositide-3-kinase regulatory subunit alpha/beta/delta.	0.937
Alk	Plcg1	ENSCCNP00000002014	ENSCCNP00000006023	ALK tyrosine kinase receptor.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1.	0.952
Alk	Plcg2	ENSCCNP00000002014	ENSCCNP00000030319	ALK tyrosine kinase receptor.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2.	0.943
Eml4	Alk	ENSCCNP00000007986	ENSCCNP00000002014	Echinoderm microtubule-associated protein-like 4 isoform X1.	ALK tyrosine kinase receptor.	0.982
Eml4	Hras	ENSCCNP00000007986	ENSCCNP00000010500	Echinoderm microtubule-associated protein-like 4 isoform X1.	GTPase HRas isoform X1.	0.922
Eml4	Jak1	ENSCCNP00000007986	ENSCCNP00000014861	Echinoderm microtubule-associated protein-like 4 isoform X1.	Tyrosine-protein kinase JAK1 isoform X1.	0.906
Eml4	Jak2	ENSCCNP00000007986	ENSCCNP00000013119	Echinoderm microtubule-associated protein-like 4 isoform X1.	Tyrosine-protein kinase JAK2 isoform X1.	0.909
Eml4	Pik3ca	ENSCCNP00000007986	ENSCCNP00000031019	Echinoderm microtubule-associated protein-like 4 isoform X1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1.	0.932
Eml4	Pik3cd	ENSCCNP00000007986	ENSCCNP00000030856	Echinoderm microtubule-associated protein-like 4 isoform X1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1.	0.908
Eml4	Pik3r1	ENSCCNP00000007986	ENSCCNP00000019333	Echinoderm microtubule-associated protein-like 4 isoform X1.	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.	0.918
Eml4	Pik3r3	ENSCCNP00000007986	ENSCCNP00000002499	Echinoderm microtubule-associated protein-like 4 isoform X1.	Phosphoinositide-3-kinase regulatory subunit alpha/beta/delta.	0.904
Eml4	Plcg1	ENSCCNP00000007986	ENSCCNP00000006023	Echinoderm microtubule-associated protein-like 4 isoform X1.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1.	0.917
Eml4	Plcg2	ENSCCNP00000007986	ENSCCNP00000030319	Echinoderm microtubule-associated protein-like 4 isoform X1.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2.	0.905