STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Nedd4lE3 ubiquitin-protein ligase NEDD4-like isoform X1. (975 aa)    
Predicted Functional Partners:
Sgk1
Serine/threonine-protein kinase Sgk1 isoform X1.
   
 0.979
Scnn1g
LOW QUALITY PROTEIN: amiloride-sensitive sodium channel subunit gamma.
    
 0.974
Scnn1a
LOW QUALITY PROTEIN: amiloride-sensitive sodium channel subunit alpha.
    
 0.968
Sfn
14-3-3 protein sigma.
    
 0.927
Dlg3
Disks large homolog 3 isoform X1.
   
 0.916
Smad3
Mothers against decapentaplegic homolog 3 isoform X1.
    
 0.912
Smad7
Mothers against decapentaplegic homolog 7 isoform X1.
    
 0.895
ENSCCNP00000004072
Amiloride-sensitive sodium channel subunit beta-like.
    
 0.869
Egfr
Epidermal growth factor receptor isoform X1.
   
 0.788
Ywhah
14-3-3 protein gamma/eta.
    
 0.775
Your Current Organism:
Castor canadensis
NCBI taxonomy Id: 51338
Other names: American beaver, C. canadensis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.