STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rb1Retinoblastoma-associated protein isoform X1. (930 aa)    
Predicted Functional Partners:
E2f1
LOW QUALITY PROTEIN: transcription factor E2F1.
   
 0.999
Cdk4
Cyclin-dependent kinase 4.
   
 0.998
Hdac1
Histone deacetylase 1/2.
   
 0.997
Ccnd1
G1/S-specific cyclin-D1.
    
 0.993
Tfdp1
Transcription factor Dp-1 isoform X1.
   
 0.992
Ccna2
Cyclin-A2.
   
 0.991
E2f2
Transcription factor E2F2.
   
 0.990
ENSCCNP00000005852
Transcription factor E2F2-like.
   
 0.990
Cdk2
Cyclin-dependent kinase 2 isoform X1.
   
 0.990
Arid4a
AT-rich interactive domain-containing protein 4A isoform X1.
   
 
 0.990
Your Current Organism:
Castor canadensis
NCBI taxonomy Id: 51338
Other names: American beaver, C. canadensis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.