STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Smad4Mothers against decapentaplegic homolog 4 isoform X1. (530 aa)    
Predicted Functional Partners:
Smad3
Mothers against decapentaplegic homolog 3 isoform X1.
   
0.999
Smad2
LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 2-like.
  
0.996
Smad5
Mothers against decapentaplegic homolog 5 isoform X1.
   
0.992
Smad9
Mothers against decapentaplegic homolog 9.
   
0.992
Tgfbr1
TGF-beta receptor type-1.
   
 0.983
E2f4
Transcription factor E2F4/5.
    
 0.982
Ski
Ski oncogene isoform X1.
   
 0.980
Smad1
Mothers against decapentaplegic homolog 1 isoform X1.
   
0.978
E2f5
Transcription factor E2F5 isoform X1.
    
 0.975
ENSCCNP00000001084
Lymphoid enhancer-binding factor 1.
    
 0.972
Your Current Organism:
Castor canadensis
NCBI taxonomy Id: 51338
Other names: American beaver, C. canadensis
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.