Cfap99 protein (Castor canadensis) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

Cfap99

Cilia- and flagella-associated protein 99. (647 aa)

Predicted Functional Partners:

Ankef1

0.610

Dnah10

0.592

ENSCCNP00000013845

0.566

Farp2

0.562

ENSCCNP00000021693

0.537

Ccdc65

0.537

Rsph6a

0.517

Rsph4a

0.508

Pank4

0.490

Abcf3

0.430

Your Current Organism:

Castor canadensis

NCBI taxonomy Id: 51338
Other names: American beaver, C. canadensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Abcf3	Cfap99	ENSCCNP00000014230	ENSCCNP00000025260	ATP-binding cassette, subfamily F, member 3.	Cilia- and flagella-associated protein 99.	0.430
Abcf3	ENSCCNP00000013845	ENSCCNP00000014230	ENSCCNP00000013845	ATP-binding cassette, subfamily F, member 3.	annotation not available	0.480
Ankef1	Ccdc65	ENSCCNP00000017194	ENSCCNP00000021702	Ankyrin repeat and EF-hand domain-containing protein 1.	Coiled-coil domain-containing protein 65.	0.502
Ankef1	Cfap99	ENSCCNP00000017194	ENSCCNP00000025260	Ankyrin repeat and EF-hand domain-containing protein 1.	Cilia- and flagella-associated protein 99.	0.610
Ankef1	Dnah10	ENSCCNP00000017194	ENSCCNP00000001834	Ankyrin repeat and EF-hand domain-containing protein 1.	LOW QUALITY PROTEIN: dynein heavy chain 10, axonemal.	0.601
Ankef1	ENSCCNP00000021693	ENSCCNP00000017194	ENSCCNP00000021693	Ankyrin repeat and EF-hand domain-containing protein 1.	annotation not available	0.502
Ankef1	Rsph4a	ENSCCNP00000017194	ENSCCNP00000025916	Ankyrin repeat and EF-hand domain-containing protein 1.	Radial spoke head protein 4 homolog A.	0.525
Ankef1	Rsph6a	ENSCCNP00000017194	ENSCCNP00000021643	Ankyrin repeat and EF-hand domain-containing protein 1.	Radial spoke head protein 6 homolog A.	0.525
Ccdc65	Ankef1	ENSCCNP00000021702	ENSCCNP00000017194	Coiled-coil domain-containing protein 65.	Ankyrin repeat and EF-hand domain-containing protein 1.	0.502
Ccdc65	Cfap99	ENSCCNP00000021702	ENSCCNP00000025260	Coiled-coil domain-containing protein 65.	Cilia- and flagella-associated protein 99.	0.537
Ccdc65	Dnah10	ENSCCNP00000021702	ENSCCNP00000001834	Coiled-coil domain-containing protein 65.	LOW QUALITY PROTEIN: dynein heavy chain 10, axonemal.	0.561
Ccdc65	ENSCCNP00000021693	ENSCCNP00000021702	ENSCCNP00000021693	Coiled-coil domain-containing protein 65.	annotation not available	0.918
Cfap99	Abcf3	ENSCCNP00000025260	ENSCCNP00000014230	Cilia- and flagella-associated protein 99.	ATP-binding cassette, subfamily F, member 3.	0.430
Cfap99	Ankef1	ENSCCNP00000025260	ENSCCNP00000017194	Cilia- and flagella-associated protein 99.	Ankyrin repeat and EF-hand domain-containing protein 1.	0.610
Cfap99	Ccdc65	ENSCCNP00000025260	ENSCCNP00000021702	Cilia- and flagella-associated protein 99.	Coiled-coil domain-containing protein 65.	0.537
Cfap99	Dnah10	ENSCCNP00000025260	ENSCCNP00000001834	Cilia- and flagella-associated protein 99.	LOW QUALITY PROTEIN: dynein heavy chain 10, axonemal.	0.592
Cfap99	ENSCCNP00000013845	ENSCCNP00000025260	ENSCCNP00000013845	Cilia- and flagella-associated protein 99.	annotation not available	0.566
Cfap99	ENSCCNP00000021693	ENSCCNP00000025260	ENSCCNP00000021693	Cilia- and flagella-associated protein 99.	annotation not available	0.537
Cfap99	Farp2	ENSCCNP00000025260	ENSCCNP00000009866	Cilia- and flagella-associated protein 99.	FERM, RhoGEF and pleckstrin domain-containing protein 2 isoform X1.	0.562
Cfap99	Pank4	ENSCCNP00000025260	ENSCCNP00000003404	Cilia- and flagella-associated protein 99.	Bifunctional protein PANK4.	0.490

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

43

average node degree:

7.82

avg. local clustering coefficient:

0.911

expected number of edges:

18

PPI enrichment p-value:

2.2e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042254

Ribosome biogenesis

9 of 392

1.59

2.92

5.41e-10

GO:0006391

Transcription initiation from mitochondrial promoter

3 of 3

3.23

2.78

9.17e-06

GO:0042274

Ribosomal small subunit biogenesis

5 of 95

1.95

2.42

7.10e-06

GO:0006364

rRNA processing

6 of 272

1.58

1.94

1.06e-05

GO:0030490

Maturation of SSU-rRNA

3 of 49

2.02

1.31

0.0029

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0034246

Mitochondrial transcription factor activity

2 of 2

3.23

1.42

0.0028

GO:0001018

Mitochondrial promoter sequence-specific DNA binding

2 of 3

3.06

1.41

0.0028

GO:0030515

snoRNA binding

3 of 39

2.12

1.34

0.0028

GO:0003723

RNA binding

10 of 1780

0.98

1.08

1.98e-06

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030684

Preribosome

4 of 75

1.96

1.86

0.00016

GO:0042645

Mitochondrial nucleoid

3 of 43

2.08

1.6

0.00079

GO:0034388

Pwp2p-containing subcomplex of 90S preribosome

2 of 5

2.84

1.54

0.0016

GO:0030688

Preribosome, small subunit precursor

2 of 13

2.42

1.25

0.0050

GO:0032040

Small-subunit processome

2 of 36

1.98

0.84

0.0261

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15888

Mixed, incl. Small-subunit processome, and Positive regulation of rRNA processing

7 of 70

2.23

4.96

1.91e-11

CL:15903

Small-subunit processome, and Positive regulation of rRNA processing

5 of 42

2.31

3.75

2.88e-08

CL:18639

Mixed, incl. Mitochondrial transcription initiation, and Helix-hairpin-helix motif

3 of 7

2.87

2.78

7.98e-06

CL:15907

Small-subunit processome, and Positive regulation of rRNA processing

3 of 27

2.28

1.92

0.00022

CL:16011

Mixed, incl. AARP2CN (NUC121) domain, and Regulation of ribosomal subunit export from nucleus

2 of 5

2.84

1.5

0.0019

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03008

Ribosome biogenesis in eukaryotes

4 of 127

1.73

1.65

0.00025

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-163282

Mitochondrial transcription initiation

3 of 3

3.23

3.18

1.71e-06

MAP-75944

Transcription from mitochondrial promoters

3 of 4

3.11

3.16

1.79e-06

MAP-6791226

Major pathway of rRNA processing in the nucleolus and cytosol

7 of 426

1.45

1.92

1.71e-06

MAP-8868773

rRNA processing in the nucleus and cytosol

7 of 441

1.43

1.9

1.71e-06

MAP-72312

rRNA processing

7 of 452

1.42

1.88

1.71e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030684

Preribosome

7 of 82

2.16

4.77

2.72e-11

GOCC:0034388

Pwp2p-containing subcomplex of 90S preribosome

3 of 7

2.87

2.75

8.98e-06

GOCC:0030686

90S preribosome

4 of 40

2.23

2.66

5.70e-06

GOCC:0030688

Preribosome, small subunit precursor

3 of 27

2.28

1.9

0.00024

GOCC:1990904

Ribonucleoprotein complex

8 of 794

1.24

1.54

1.56e-06

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04003

Dip2/Utp12 Family

2 of 3

3.06

1.19

0.0072

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