STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Siah1E3 ubiquitin-protein ligase SIAH1 isoform X1. (282 aa)    
Predicted Functional Partners:
ENSCCNP00000003772
Calcyclin-binding protein isoform X1.
    
 0.988
Ctnnb1
Catenin beta 1.
    
 0.960
ENSCCNP00000002206
annotation not available
    
 
 0.894
Axin1
Axin-1 isoform X1.
    
 0.894
Usp19
Ubiquitin carboxyl-terminal hydrolase 19 isoform X1.
    
 
 0.831
Snca
Alpha-synuclein isoform X1.
    
 0.729
Sncaip
Synphilin-1 isoform X1.
    
 0.721
ENSCCNP00000027033
annotation not available
    
   0.719
Ube2l6
Ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X1.
   
 0.696
Siah2
E3 ubiquitin-protein ligase SIAH2.
  
 
0.679
Your Current Organism:
Castor canadensis
NCBI taxonomy Id: 51338
Other names: American beaver, C. canadensis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.