node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADD79450.1 | glyA | RIEPE_0112 | RIEPE_0331 | Inosine-5'-monophosphate dehydrogenase; Identified by match to protein family HMM PF00478. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.660 |
ADD79450.1 | guaA | RIEPE_0112 | RIEPE_0111 | Inosine-5'-monophosphate dehydrogenase; Identified by match to protein family HMM PF00478. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.999 |
ADD79450.1 | hpt | RIEPE_0112 | RIEPE_0203 | Inosine-5'-monophosphate dehydrogenase; Identified by match to protein family HMM PF00478. | Hypoxanthine phosphoribosyltransferase; Identified by match to protein family HMM PF00156; match to protein family HMM TIGR01203; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.928 |
ADD79450.1 | pheT | RIEPE_0112 | RIEPE_0099 | Inosine-5'-monophosphate dehydrogenase; Identified by match to protein family HMM PF00478. | phenylalanyl-tRNA synthetase, beta subunit; Identified by match to protein family HMM PF03147; match to protein family HMM PF03483; match to protein family HMM PF03484; match to protein family HMM TIGR00472; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.888 |
ADD79450.1 | purA | RIEPE_0112 | RIEPE_0256 | Inosine-5'-monophosphate dehydrogenase; Identified by match to protein family HMM PF00478. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.985 |
ADD79450.1 | purB | RIEPE_0112 | RIEPE_0184 | Inosine-5'-monophosphate dehydrogenase; Identified by match to protein family HMM PF00478. | Adenylosuccinate lyase; Identified by match to protein family HMM PF00206; match to protein family HMM TIGR00928; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.821 |
ADD79450.1 | pyrG | RIEPE_0112 | RIEPE_0212 | Inosine-5'-monophosphate dehydrogenase; Identified by match to protein family HMM PF00478. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.737 |
ADD79450.1 | ribH | RIEPE_0112 | RIEPE_0177 | Inosine-5'-monophosphate dehydrogenase; Identified by match to protein family HMM PF00478. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. | 0.676 |
ADD79450.1 | rpoB | RIEPE_0112 | RIEPE_0405 | Inosine-5'-monophosphate dehydrogenase; Identified by match to protein family HMM PF00478. | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.787 |
ADD79450.1 | tkt | RIEPE_0112 | RIEPE_0218 | Inosine-5'-monophosphate dehydrogenase; Identified by match to protein family HMM PF00478. | Transketolase; Identified by match to protein family HMM PF00456; match to protein family HMM PF02779; match to protein family HMM PF02780; match to protein family HMM TIGR00232; Belongs to the transketolase family. | 0.706 |
glyA | ADD79450.1 | RIEPE_0331 | RIEPE_0112 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Inosine-5'-monophosphate dehydrogenase; Identified by match to protein family HMM PF00478. | 0.660 |
glyA | guaA | RIEPE_0331 | RIEPE_0111 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.637 |
glyA | pheT | RIEPE_0331 | RIEPE_0099 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | phenylalanyl-tRNA synthetase, beta subunit; Identified by match to protein family HMM PF03147; match to protein family HMM PF03483; match to protein family HMM PF03484; match to protein family HMM TIGR00472; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.585 |
glyA | purA | RIEPE_0331 | RIEPE_0256 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.872 |
glyA | purB | RIEPE_0331 | RIEPE_0184 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Adenylosuccinate lyase; Identified by match to protein family HMM PF00206; match to protein family HMM TIGR00928; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.835 |
glyA | tkt | RIEPE_0331 | RIEPE_0218 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Transketolase; Identified by match to protein family HMM PF00456; match to protein family HMM PF02779; match to protein family HMM PF02780; match to protein family HMM TIGR00232; Belongs to the transketolase family. | 0.416 |
guaA | ADD79450.1 | RIEPE_0111 | RIEPE_0112 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase; Identified by match to protein family HMM PF00478. | 0.999 |
guaA | glyA | RIEPE_0111 | RIEPE_0331 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.637 |
guaA | hpt | RIEPE_0111 | RIEPE_0203 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Hypoxanthine phosphoribosyltransferase; Identified by match to protein family HMM PF00156; match to protein family HMM TIGR01203; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.959 |
guaA | pheT | RIEPE_0111 | RIEPE_0099 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | phenylalanyl-tRNA synthetase, beta subunit; Identified by match to protein family HMM PF03147; match to protein family HMM PF03483; match to protein family HMM PF03484; match to protein family HMM TIGR00472; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.928 |