Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
trpFPhosphoribosylanthranilate isomerase TrpF; Belongs to the TrpF family. (215 aa)    
Predicted Functional Partners:
trpB1
Tryptophan synthase beta subunit TrpB1; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
  
 0.999
trpC
Indole-3-glycerol phosphate synthase TrpC; Belongs to the TrpC family.
 
 0.999
trpD
Anthranilate phosphoribosyltransferase TrpD; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 
 
 0.999
trpA
Tryptophan synthase alpha subunit TrpA; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 
  
 0.997
trpE
Anthranilate synthase component I TrpE; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high con [...]
 
  
 0.984
trpG
Anthranilate synthase component II TrpG.
 
  
 0.981
pheA
Chorismate mutase/prephenate dehydratase PheA.
 
  
 0.743
hisIE
Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein HisIE; In the C-terminal section; belongs to the PRA-PH family.
     
 0.698
aroE
Shikimate 5-dehydrogenase/shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate dehydrogenase family.
     
 0.622
ilvA
Threonine dehydratase IlvA.
  
  
 0.514
Your Current Organism:
Butyrivibrio proteoclasticus
NCBI taxonomy Id: 515622
Other names: B. proteoclasticus B316, Butyrivibrio proteoclasticus B316, Butyrivibrio proteoclasticus str. B316, Butyrivibrio proteoclasticus strain B316
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.