node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
alr | ddlA | bpr_I1209 | bpr_I2793 | Alanine racemase Alr; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | D-alanine-D-alanine ligase DdlA; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | 0.958 |
alr | murA | bpr_I1209 | bpr_I0563 | Alanine racemase Alr; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.476 |
alr | murC | bpr_I1209 | bpr_I0289 | Alanine racemase Alr; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | UDP-N-acetylmuramate-alanine ligase MurC; Cell wall formation; Belongs to the MurCDEF family. | 0.575 |
alr | murD | bpr_I1209 | bpr_I1865 | Alanine racemase Alr; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | UDP-N-acetylmuramoylalanine-D-glutamate ligase MurD; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.737 |
alr | murI | bpr_I1209 | bpr_I2919 | Alanine racemase Alr; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Glutamate racemase MurI; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.635 |
bpr_I2470 | murI | bpr_I2470 | bpr_I2919 | Non-canonical purine NTP pyrophosphatase rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase MurI; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.924 |
bpr_I2920 | murI | bpr_I2920 | bpr_I2919 | Hypothetical protein. | Glutamate racemase MurI; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.560 |
ddlA | alr | bpr_I2793 | bpr_I1209 | D-alanine-D-alanine ligase DdlA; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Alanine racemase Alr; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | 0.958 |
ddlA | murA | bpr_I2793 | bpr_I0563 | D-alanine-D-alanine ligase DdlA; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.662 |
ddlA | murC | bpr_I2793 | bpr_I0289 | D-alanine-D-alanine ligase DdlA; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | UDP-N-acetylmuramate-alanine ligase MurC; Cell wall formation; Belongs to the MurCDEF family. | 0.982 |
ddlA | murD | bpr_I2793 | bpr_I1865 | D-alanine-D-alanine ligase DdlA; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | UDP-N-acetylmuramoylalanine-D-glutamate ligase MurD; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.813 |
ddlA | murG | bpr_I2793 | bpr_I0030 | D-alanine-D-alanine ligase DdlA; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Undecaprenyldiphospho- muramoylpentapeptide beta-N-acetylglucosaminyltransferase MurG; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.834 |
ddlA | murI | bpr_I2793 | bpr_I2919 | D-alanine-D-alanine ligase DdlA; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Glutamate racemase MurI; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.623 |
gltB | glyA | bpr_I0123 | bpr_I1796 | Glutamate synthase large subunit GltB. | Serine hydroxymethyltransferase GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.498 |
gltB | murA | bpr_I0123 | bpr_I0563 | Glutamate synthase large subunit GltB. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.551 |
gltB | murD | bpr_I0123 | bpr_I1865 | Glutamate synthase large subunit GltB. | UDP-N-acetylmuramoylalanine-D-glutamate ligase MurD; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.560 |
gltB | murI | bpr_I0123 | bpr_I2919 | Glutamate synthase large subunit GltB. | Glutamate racemase MurI; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.713 |
glyA | gltB | bpr_I1796 | bpr_I0123 | Serine hydroxymethyltransferase GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Glutamate synthase large subunit GltB. | 0.498 |
glyA | murA | bpr_I1796 | bpr_I0563 | Serine hydroxymethyltransferase GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.430 |
glyA | murI | bpr_I1796 | bpr_I2919 | Serine hydroxymethyltransferase GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Glutamate racemase MurI; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.576 |