Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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larCHypothetical protein; Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes. Belongs to the LarC family. (422 aa)    
Predicted Functional Partners:
bpr_I1983
PP-loop family protein.
 
 0.973
bpr_I0851
NCAIR mutase-related protein.
  
 0.958
cbiM
Cobalamin biosynthesis protein CbiM.
 
    0.695
hypB2
Hydrogenase accessory protein HypB2.
       0.678
cbiQ
Cobalt ABC transporter permease protein CbiQ.
 
    0.620
bpr_I1775
Hypothetical protein.
 
    0.538
hypA2
Hydrogenase nickel insertion protein HypA2.
       0.520
ADL35698.1
GGDEF/GAF domain-containing protein.
       0.508
ADL35699.1
GGDEF domain-containing protein.
       0.480
bpr_I2283
Iron-sulfur cluster-binding protein.
 
     0.429
Your Current Organism:
Butyrivibrio proteoclasticus
NCBI taxonomy Id: 515622
Other names: B. proteoclasticus B316, Butyrivibrio proteoclasticus B316, Butyrivibrio proteoclasticus str. B316, Butyrivibrio proteoclasticus strain B316
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