node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dtur_1119 | hisA | Dtur_1119 | Dtur_1125 | PFAM: tRNA synthetase class II (G H P and S); KEGG: dth:DICTH_0991 histidyl-tRNA synthetase, putative. | PFAM: histidine biosynthesis protein; KEGG: dth:DICTH_0997 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imid azole-4-carboxamide isomerase. | 0.840 |
Dtur_1119 | hisB | Dtur_1119 | Dtur_1123 | PFAM: tRNA synthetase class II (G H P and S); KEGG: dth:DICTH_0991 histidyl-tRNA synthetase, putative. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: dth:DICTH_0995 imidazoleglycerol-phosphate dehydratase. | 0.810 |
Dtur_1119 | hisC | Dtur_1119 | Dtur_1122 | PFAM: tRNA synthetase class II (G H P and S); KEGG: dth:DICTH_0991 histidyl-tRNA synthetase, putative. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: dth:DICTH_0994 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.807 |
Dtur_1119 | hisD | Dtur_1119 | Dtur_1121 | PFAM: tRNA synthetase class II (G H P and S); KEGG: dth:DICTH_0991 histidyl-tRNA synthetase, putative. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.808 |
Dtur_1119 | hisF | Dtur_1119 | Dtur_1126 | PFAM: tRNA synthetase class II (G H P and S); KEGG: dth:DICTH_0991 histidyl-tRNA synthetase, putative. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.834 |
Dtur_1119 | hisG | Dtur_1119 | Dtur_1120 | PFAM: tRNA synthetase class II (G H P and S); KEGG: dth:DICTH_0991 histidyl-tRNA synthetase, putative. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.992 |
Dtur_1119 | hisH | Dtur_1119 | Dtur_1124 | PFAM: tRNA synthetase class II (G H P and S); KEGG: dth:DICTH_0991 histidyl-tRNA synthetase, putative. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.812 |
Dtur_1119 | hisI | Dtur_1119 | Dtur_1127 | PFAM: tRNA synthetase class II (G H P and S); KEGG: dth:DICTH_0991 histidyl-tRNA synthetase, putative. | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: dth:DICTH_0999 histidine biosynthesis bifunctional protein hisIE; In the N-terminal section; belongs to the PRA-CH family. | 0.987 |
Dtur_1423 | hisF | Dtur_1423 | Dtur_1126 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: dth:DICTH_1317 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.809 |
Dtur_1423 | hisH | Dtur_1423 | Dtur_1124 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: dth:DICTH_1317 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.809 |
Dtur_1423 | hisI | Dtur_1423 | Dtur_1127 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: dth:DICTH_1317 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: dth:DICTH_0999 histidine biosynthesis bifunctional protein hisIE; In the N-terminal section; belongs to the PRA-CH family. | 0.442 |
Dtur_1423 | purH | Dtur_1423 | Dtur_0847 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: dth:DICTH_1317 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | KEGG: dth:DICTH_0690 bifunctional purine biosynthesis protein PurH; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.992 |
hisA | Dtur_1119 | Dtur_1125 | Dtur_1119 | PFAM: histidine biosynthesis protein; KEGG: dth:DICTH_0997 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imid azole-4-carboxamide isomerase. | PFAM: tRNA synthetase class II (G H P and S); KEGG: dth:DICTH_0991 histidyl-tRNA synthetase, putative. | 0.840 |
hisA | hisB | Dtur_1125 | Dtur_1123 | PFAM: histidine biosynthesis protein; KEGG: dth:DICTH_0997 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imid azole-4-carboxamide isomerase. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: dth:DICTH_0995 imidazoleglycerol-phosphate dehydratase. | 0.996 |
hisA | hisC | Dtur_1125 | Dtur_1122 | PFAM: histidine biosynthesis protein; KEGG: dth:DICTH_0997 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imid azole-4-carboxamide isomerase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: dth:DICTH_0994 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.992 |
hisA | hisD | Dtur_1125 | Dtur_1121 | PFAM: histidine biosynthesis protein; KEGG: dth:DICTH_0997 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imid azole-4-carboxamide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.996 |
hisA | hisF | Dtur_1125 | Dtur_1126 | PFAM: histidine biosynthesis protein; KEGG: dth:DICTH_0997 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imid azole-4-carboxamide isomerase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | Dtur_1125 | Dtur_1120 | PFAM: histidine biosynthesis protein; KEGG: dth:DICTH_0997 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imid azole-4-carboxamide isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.996 |
hisA | hisH | Dtur_1125 | Dtur_1124 | PFAM: histidine biosynthesis protein; KEGG: dth:DICTH_0997 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imid azole-4-carboxamide isomerase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | Dtur_1125 | Dtur_1127 | PFAM: histidine biosynthesis protein; KEGG: dth:DICTH_0997 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imid azole-4-carboxamide isomerase. | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: dth:DICTH_0999 histidine biosynthesis bifunctional protein hisIE; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |