STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (119 aa)    
Predicted Functional Partners:
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
 
 0.999
SIT75689.1
Aminomethyltransferase.
 0.997
SIT87091.1
Aminomethyltransferase; Belongs to the GcvT family.
 0.992
SIT80767.1
Aminomethyltransferase; Belongs to the GcvT family.
 
 0.976
SIT82332.1
Aminomethyltransferase; Belongs to the GcvT family.
 0.971
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.971
SIT76144.1
4-methylaminobutanoate oxidase (formaldehyde-forming); Belongs to the GcvT family.
 
 0.956
SIT77808.1
4-methylaminobutanoate oxidase (formaldehyde-forming); Belongs to the GcvT family.
  
 0.950
SIT82695.1
Dimethylglycine dehydrogenase; Belongs to the GcvT family.
  
 0.950
SIT77287.1
Sarcosine oxidase subunit alpha; Belongs to the GcvT family.
  
 0.949
Your Current Organism:
Pontibaca methylaminivorans
NCBI taxonomy Id: 515897
Other names: DSM 21219, KCTC 22497, P. methylaminivorans, Pontibaca methylaminivorans Kim et al. 2010, alpha proteobacterium GRP21, alpha proteobacterium PH34, strain GRP21
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