STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SIT83194.1Glyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (324 aa)    
Predicted Functional Partners:
SIT81174.1
Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine.
 
   
 0.929
SIT75723.1
Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
  
 
 0.808
SIT78827.1
FAD/FMN-containing dehydrogenase.
   
 0.797
SIT82964.1
Glyoxylate/hydroxypyruvate reductase A.
 
  
 
0.791
SIT83174.1
beta-methylmalyl-CoA/L-malyl-CoA lyase; Belongs to the HpcH/HpaI aldolase family.
 
  
 0.782
sucC-2
Malate thiokinase large subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.782
SIT86609.1
Prokaryotic molybdopterin-containing oxidoreductase family, iron-sulfur binding subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
     
 0.770
sucD-2
Malate thiokinase small subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 
 0.766
SIT82140.1
2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway).
 
  0.762
SIT75835.1
Phosphate butyryltransferase.
  
 0.733
Your Current Organism:
Pontibaca methylaminivorans
NCBI taxonomy Id: 515897
Other names: DSM 21219, KCTC 22497, P. methylaminivorans, Pontibaca methylaminivorans Kim et al. 2010, alpha proteobacterium GRP21, alpha proteobacterium PH34, strain GRP21
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