| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| VC82_1180 | VC82_1747 | VC82_1180 | VC82_1747 | Pfam:pfam03301 Tryptophan 2,3-dioxygenase. | N-formylkynurenine (Aryl-) formamidase; Pfam:pfam04199 Putative cyclase. | 0.763 |
| VC82_1180 | VC82_2852 | VC82_1180 | VC82_2852 | Pfam:pfam03301 Tryptophan 2,3-dioxygenase. | ABC transporter substrate-binding protein; Pfam:pfam09084 NMT1/THI5 like. | 0.486 |
| VC82_1180 | kmo | VC82_1180 | VC82_2174 | Pfam:pfam03301 Tryptophan 2,3-dioxygenase. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid; Belongs to the aromatic-ring hydroxylase family. KMO subfamily. | 0.778 |
| VC82_1180 | kynU | VC82_1180 | VC82_2165 | Pfam:pfam03301 Tryptophan 2,3-dioxygenase. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. | 0.990 |
| VC82_1180 | nbaC | VC82_1180 | VC82_1217 | Pfam:pfam03301 Tryptophan 2,3-dioxygenase. | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. | 0.673 |
| VC82_1747 | VC82_1180 | VC82_1747 | VC82_1180 | N-formylkynurenine (Aryl-) formamidase; Pfam:pfam04199 Putative cyclase. | Pfam:pfam03301 Tryptophan 2,3-dioxygenase. | 0.763 |
| VC82_1747 | kmo | VC82_1747 | VC82_2174 | N-formylkynurenine (Aryl-) formamidase; Pfam:pfam04199 Putative cyclase. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid; Belongs to the aromatic-ring hydroxylase family. KMO subfamily. | 0.609 |
| VC82_1747 | kynU | VC82_1747 | VC82_2165 | N-formylkynurenine (Aryl-) formamidase; Pfam:pfam04199 Putative cyclase. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. | 0.882 |
| VC82_1747 | nbaC | VC82_1747 | VC82_1217 | N-formylkynurenine (Aryl-) formamidase; Pfam:pfam04199 Putative cyclase. | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. | 0.527 |
| VC82_2164 | VC82_2166 | VC82_2164 | VC82_2166 | N-acetyltransferase GCN5; Pfam:pfam00583 Acetyltransferase (GNAT) family. | MFS transporter permease; Pfam:pfam07690 Major Facilitator Superfamily. | 0.625 |
| VC82_2164 | kynU | VC82_2164 | VC82_2165 | N-acetyltransferase GCN5; Pfam:pfam00583 Acetyltransferase (GNAT) family. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. | 0.657 |
| VC82_2166 | VC82_2164 | VC82_2166 | VC82_2164 | MFS transporter permease; Pfam:pfam07690 Major Facilitator Superfamily. | N-acetyltransferase GCN5; Pfam:pfam00583 Acetyltransferase (GNAT) family. | 0.625 |
| VC82_2166 | kynU | VC82_2166 | VC82_2165 | MFS transporter permease; Pfam:pfam07690 Major Facilitator Superfamily. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. | 0.679 |
| VC82_2852 | VC82_1180 | VC82_2852 | VC82_1180 | ABC transporter substrate-binding protein; Pfam:pfam09084 NMT1/THI5 like. | Pfam:pfam03301 Tryptophan 2,3-dioxygenase. | 0.486 |
| VC82_2852 | kmo | VC82_2852 | VC82_2174 | ABC transporter substrate-binding protein; Pfam:pfam09084 NMT1/THI5 like. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid; Belongs to the aromatic-ring hydroxylase family. KMO subfamily. | 0.594 |
| VC82_2852 | kynU | VC82_2852 | VC82_2165 | ABC transporter substrate-binding protein; Pfam:pfam09084 NMT1/THI5 like. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. | 0.579 |
| VC82_2852 | nbaC | VC82_2852 | VC82_1217 | ABC transporter substrate-binding protein; Pfam:pfam09084 NMT1/THI5 like. | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. | 0.705 |
| VC82_824 | kynU | VC82_824 | VC82_2165 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. | 0.466 |
| katG | kynU | VC82_1163 | VC82_2165 | Catalase/hydroperoxidase HPI(I); Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. | 0.900 |
| katG | nbaC | VC82_1163 | VC82_1217 | Catalase/hydroperoxidase HPI(I); Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. | 0.900 |