Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
VC82_2292Molecular chaperone Hsp90; Molecular chaperone. Has ATPase activity. (628 aa)    
Predicted Functional Partners:
dnaK
Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
   
 0.980
VC82_270
Pfam:pfam00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD.
  
 0.963
VC82_469
Peptidylprolyl isomerase; Pfam:pfam00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD.
  
 0.963
groL
60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
   
 
 0.918
VC82_1381
Hypothetical protein; Pfam:pfam00226 DnaJ domain.
 
 0.839
groS
Molecular chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
  
 
 0.831
VC82_1525
Heat shock protein DnaJ-like protein; Pfam:pfam05099 Tellurite resistance protein TerB.
  
 0.824
dnaJ
Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...]
  
 0.818
VC82_2450
ATPase AAA-2 domain protein; Pfam:pfam07724 AAA domain (Cdc48 subfamily); Belongs to the ClpA/ClpB family.
  
 
 0.766
grpE
Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
   
 
 0.763
Your Current Organism:
Muricauda lutaonensis
NCBI taxonomy Id: 516051
Other names: BCRC 17850, KCTC 22339, M. lutaonensis, Muricauda lutaonensis Arun et al. 2009 emend. Hahnke et al. 2016, Muricauda sp. CC-HSB-11, strain CC-HSB-11
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