node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
VC82_1256 | fhs | VC82_1256 | VC82_2878 | Amidophosphoribosyltransferase. | Pfam:pfam01268 Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.723 |
VC82_1256 | folD | VC82_1256 | VC82_722 | Amidophosphoribosyltransferase. | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.520 |
VC82_1256 | glyA | VC82_1256 | VC82_3004 | Amidophosphoribosyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.740 |
VC82_1256 | purC | VC82_1256 | VC82_2552 | Amidophosphoribosyltransferase. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Pfam:pfam01259 SAICAR synthetase. | 0.953 |
VC82_1256 | purH | VC82_1256 | VC82_969 | Amidophosphoribosyltransferase. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Pfam:pfam01808 AICARFT/IMPCHase bienzyme. | 0.947 |
VC82_1256 | purL | VC82_1256 | VC82_88 | Amidophosphoribosyltransferase. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.999 |
VC82_1256 | purN | VC82_1256 | VC82_1253 | Amidophosphoribosyltransferase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.978 |
VC82_2016 | VC82_2061 | VC82_2016 | VC82_2061 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.900 |
VC82_2016 | fhs | VC82_2016 | VC82_2878 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Pfam:pfam01268 Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.915 |
VC82_2016 | gcvT | VC82_2016 | VC82_2457 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.911 |
VC82_2016 | glyA | VC82_2016 | VC82_3004 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.916 |
VC82_2016 | purH | VC82_2016 | VC82_969 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Pfam:pfam01808 AICARFT/IMPCHase bienzyme. | 0.911 |
VC82_2016 | purN | VC82_2016 | VC82_1253 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.912 |
VC82_2061 | VC82_2016 | VC82_2061 | VC82_2016 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.900 |
VC82_2061 | fhs | VC82_2061 | VC82_2878 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Pfam:pfam01268 Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.927 |
VC82_2061 | gcvT | VC82_2061 | VC82_2457 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.919 |
VC82_2061 | glyA | VC82_2061 | VC82_3004 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.921 |
VC82_2061 | purH | VC82_2061 | VC82_969 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Pfam:pfam01808 AICARFT/IMPCHase bienzyme. | 0.900 |
VC82_2061 | purN | VC82_2061 | VC82_1253 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.900 |
fhs | VC82_1256 | VC82_2878 | VC82_1256 | Pfam:pfam01268 Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Amidophosphoribosyltransferase. | 0.723 |