Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
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gene neighborhood
gene co-occurrence
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sucCmalate--CoA ligase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (397 aa)    
Predicted Functional Partners:
sucD
succinate--CoA ligase; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 0.999
VC82_1437
Succinate dehydrogenase; Pfam:pfam13085 2Fe-2S iron-sulfur cluster binding domain; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
  
 0.977
VC82_1877
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 
 0.977
VC82_1876
2-oxoglutarate dehydrogenase, E1 subunit; Pfam:pfam00676 Dehydrogenase E1 component.
 
 0.975
VC82_1438
Succinate dehydrogenase; Pfam:pfam00890 FAD binding domain.
  
 0.969
VC82_824
Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 0.946
VC82_1603
Pfam:pfam01642 Methylmalonyl-CoA mutase.
  
 
 0.926
VC82_737
Pfam:pfam00285 Citrate synthase; Belongs to the citrate synthase family.
  
 0.920
VC82_1439
Succinate dehydrogenase (Or fumarate reductase) cytochrome b subunit, b558 family.
    
 0.915
VC82_247
Pfam:pfam01642 Methylmalonyl-CoA mutase.
  
 
 0.907
Your Current Organism:
Muricauda lutaonensis
NCBI taxonomy Id: 516051
Other names: BCRC 17850, KCTC 22339, M. lutaonensis, Muricauda lutaonensis Arun et al. 2009 emend. Hahnke et al. 2016, Muricauda sp. CC-HSB-11, strain CC-HSB-11
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