Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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icmFMethylmalonyl-CoA mutase; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1151 aa)    
Predicted Functional Partners:
VC82_1603
Pfam:pfam01642 Methylmalonyl-CoA mutase.
 
 
0.999
VC82_405
Pfam:pfam03308 ArgK protein.
 
 
0.978
VC82_247
Pfam:pfam01642 Methylmalonyl-CoA mutase.
 
 
0.971
VC82_1830
Pfam:pfam13336 Acetyl-CoA hydrolase/transferase C-terminal domain.
  
  
 0.759
VC82_1303
Methylmalonyl-CoA epimerase; Pfam:pfam13669 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily.
 
 
 0.751
VC82_92
Pfam:pfam02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain.
 
  
 0.693
purU
Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).
       0.582
VC82_3019
Pfam:pfam02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain.
 
   
 0.524
VC82_1910
Pfam:pfam00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily.
     
 0.495
VC82_2557
acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
     
 0.494
Your Current Organism:
Muricauda lutaonensis
NCBI taxonomy Id: 516051
Other names: BCRC 17850, KCTC 22339, M. lutaonensis, Muricauda lutaonensis Arun et al. 2009 emend. Hahnke et al. 2016, Muricauda sp. CC-HSB-11, strain CC-HSB-11
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