node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SCZ84635.1 | SCZ85274.1 | NSMM_240019 | NSMM_370053 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Putative glutamate--cysteine ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | 0.551 |
SCZ84635.1 | ffh | NSMM_240019 | NSMM_370005 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Signal Recognition Particle (SRP) component with 4.5S RNA (ffs); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex [...] | 0.494 |
SCZ84635.1 | ftsY | NSMM_240019 | NSMM_410010 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Signal recognition particle receptor FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. | 0.522 |
SCZ84635.1 | secA | NSMM_240019 | NSMM_630020 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Preprotein translocase subunit, ATPase; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. | 0.520 |
SCZ84635.1 | secD | NSMM_240019 | NSMM_370043 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | SecYEG protein translocase auxillary subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.523 |
SCZ84635.1 | secE | NSMM_240019 | NSMM_640002 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | tRNA-Trp; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family. | 0.523 |
SCZ84635.1 | secF | NSMM_240019 | NSMM_370042 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Protein translocase subunit SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.523 |
SCZ84635.1 | secG | NSMM_240019 | NSMM_50013 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Protein-export membrane protein SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | 0.521 |
SCZ84635.1 | secY | NSMM_240019 | NSMM_360022 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Preprotein translocase membrane subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.523 |
SCZ84635.1 | yidC | NSMM_240019 | NSMM_410036 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Membrane protein insertase YidC; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.496 |
SCZ85274.1 | SCZ84635.1 | NSMM_370053 | NSMM_240019 | Putative glutamate--cysteine ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.551 |
SCZ85274.1 | ffh | NSMM_370053 | NSMM_370005 | Putative glutamate--cysteine ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Signal Recognition Particle (SRP) component with 4.5S RNA (ffs); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex [...] | 0.504 |
SCZ85274.1 | ftsY | NSMM_370053 | NSMM_410010 | Putative glutamate--cysteine ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Signal recognition particle receptor FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. | 0.496 |
SCZ85274.1 | secA | NSMM_370053 | NSMM_630020 | Putative glutamate--cysteine ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Preprotein translocase subunit, ATPase; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. | 0.618 |
SCZ85274.1 | secE | NSMM_370053 | NSMM_640002 | Putative glutamate--cysteine ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | tRNA-Trp; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family. | 0.966 |
SCZ85274.1 | secF | NSMM_370053 | NSMM_370042 | Putative glutamate--cysteine ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Protein translocase subunit SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.994 |
SCZ85274.1 | secG | NSMM_370053 | NSMM_50013 | Putative glutamate--cysteine ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Protein-export membrane protein SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | 0.976 |
SCZ85274.1 | secY | NSMM_370053 | NSMM_360022 | Putative glutamate--cysteine ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Preprotein translocase membrane subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.967 |
SCZ85274.1 | yidC | NSMM_370053 | NSMM_410036 | Putative glutamate--cysteine ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Membrane protein insertase YidC; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.976 |
ffh | SCZ84635.1 | NSMM_370005 | NSMM_240019 | Signal Recognition Particle (SRP) component with 4.5S RNA (ffs); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex [...] | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.494 |