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second shell of interactors
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ADU72_2139Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (171 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
 
 
 0.999
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.941
ADU72_1330
Dihydrofolate synthase at Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family.
     
 0.930
ADU72_1776
Dihydrofolate synthase at Folylpolyglutamate synthase.
     
 0.930
fhs
Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.
  
 
 0.922
cca
tRNA nucleotidyltransferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
       0.768
ADU72_2141
ATPase component of ABC transporter with duplicated ATPase domain.
   
 
 0.720
ADU72_2138
Hypothetical protein.
     
 0.689
clpX
ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
   
 
 0.634
ADU72_1328
Dihydropteroate synthase.
     
 0.595
Your Current Organism:
Pediococcus damnosus
NCBI taxonomy Id: 51663
Other names: ATCC 29358, CCUG 32251, CIP 102264, DSM 20331, JCM 5886, LMG 11484, LMG:11484, NCIMB 12010, P. damnosus, strain Be.1
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