node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFV26728.1 | SFV37140.1 | SAMN04488557_0569 | SAMN04488557_3013 | Glutamate synthase (NADH) large subunit. | GMP synthase-Glutamine amidotransferase. | 0.609 |
SFV26728.1 | SFV37892.1 | SAMN04488557_0569 | SAMN04488557_3390 | Glutamate synthase (NADH) large subunit. | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.429 |
SFV26728.1 | guaA | SAMN04488557_0569 | SAMN04488557_2440 | Glutamate synthase (NADH) large subunit. | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | 0.847 |
SFV26728.1 | guaB | SAMN04488557_0569 | SAMN04488557_2447 | Glutamate synthase (NADH) large subunit. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.838 |
SFV26728.1 | nadE | SAMN04488557_0569 | SAMN04488557_4137 | Glutamate synthase (NADH) large subunit. | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.775 |
SFV34279.1 | SFV37140.1 | SAMN04488557_2275 | SAMN04488557_3013 | CBS domain-containing protein. | GMP synthase-Glutamine amidotransferase. | 0.686 |
SFV34279.1 | SFV37892.1 | SAMN04488557_2275 | SAMN04488557_3390 | CBS domain-containing protein. | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.507 |
SFV34279.1 | guaA | SAMN04488557_2275 | SAMN04488557_2440 | CBS domain-containing protein. | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | 0.868 |
SFV34279.1 | guaB | SAMN04488557_2275 | SAMN04488557_2447 | CBS domain-containing protein. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.795 |
SFV37140.1 | SFV26728.1 | SAMN04488557_3013 | SAMN04488557_0569 | GMP synthase-Glutamine amidotransferase. | Glutamate synthase (NADH) large subunit. | 0.609 |
SFV37140.1 | SFV34279.1 | SAMN04488557_3013 | SAMN04488557_2275 | GMP synthase-Glutamine amidotransferase. | CBS domain-containing protein. | 0.686 |
SFV37140.1 | SFV37892.1 | SAMN04488557_3013 | SAMN04488557_3390 | GMP synthase-Glutamine amidotransferase. | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.639 |
SFV37140.1 | apt | SAMN04488557_3013 | SAMN04488557_0762 | GMP synthase-Glutamine amidotransferase. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.724 |
SFV37140.1 | argS | SAMN04488557_3013 | SAMN04488557_1825 | GMP synthase-Glutamine amidotransferase. | arginyl-tRNA synthetase. | 0.600 |
SFV37140.1 | gmk | SAMN04488557_3013 | SAMN04488557_3996 | GMP synthase-Glutamine amidotransferase. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.827 |
SFV37140.1 | guaA | SAMN04488557_3013 | SAMN04488557_2440 | GMP synthase-Glutamine amidotransferase. | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | 0.653 |
SFV37140.1 | guaB | SAMN04488557_3013 | SAMN04488557_2447 | GMP synthase-Glutamine amidotransferase. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.981 |
SFV37140.1 | nadE | SAMN04488557_3013 | SAMN04488557_4137 | GMP synthase-Glutamine amidotransferase. | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.594 |
SFV37140.1 | rplK | SAMN04488557_3013 | SAMN04488557_1636 | GMP synthase-Glutamine amidotransferase. | LSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | 0.624 |
SFV37892.1 | SFV26728.1 | SAMN04488557_3390 | SAMN04488557_0569 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate synthase (NADH) large subunit. | 0.429 |