STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ctha_2553PFAM: ATP-grasp domain protein; KEGG: cte:CT1089 citrate lyase, subunit 1. (398 aa)    
Predicted Functional Partners:
Ctha_2552
PFAM: CoA-binding domain protein; ATP-citrate lyase/succinyl-CoA ligase; KEGG: cph:Cpha266_1306 ATP citrate lyase subunit 2.
 0.999
sucD
succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 0.999
Ctha_2569
TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: dehydrogenase E1 component; catalytic domain of components of various dehydrogenase complexes; Transketolase central region; KEGG: sus:Acid_5307 alpha-ketoglutarate decarboxylase.
  
 
 0.992
Ctha_0613
KEGG: smd:Smed_1144 type II citrate synthase; TIGRFAM: citrate synthase I; PFAM: Citrate synthase; Belongs to the citrate synthase family.
  
 0.985
Ctha_0743
PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: cte:CT1628 pyruvate flavodoxin/ferrodoxin oxidoreductase.
  
 
 0.960
mdh
Malate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 0.950
Ctha_1492
PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: plt:Plut_1954 2-oxoglutarate ferredoxin oxidoreductase, alpha subunit.
  
 
 0.943
Ctha_2453
KEGG: lbl:LBL_4254 aconitate hydratase; TIGRFAM: aconitate hydratase; PFAM: aconitate hydratase domain protein.
 
 0.938
Ctha_2195
KEGG: cpr:CPR_1696 phosphate acetyltransferase; TIGRFAM: phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase.
  
 
 0.923
Ctha_0706
acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
  
 
 0.919
Your Current Organism:
Chloroherpeton thalassium
NCBI taxonomy Id: 517418
Other names: C. thalassium ATCC 35110, Chloroherpeton thalassium ATCC 35110, Chloroherpeton thalassium str. ATCC 35110, Chloroherpeton thalassium strain ATCC 35110
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