STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EEC91201.1Hypothetical protein; KEGG: gka:GK2561 1.8e-63 ATP-dependent exonuclease V K03581; Psort location: Cytoplasmic, score: 8.87. (351 aa)    
Predicted Functional Partners:
EEC91171.1
Hypothetical protein; KEGG: stc:str1767 5.4e-42 recD; exodeoxyribonuclease V K03581; Psort location: Cytoplasmic, score: 8.87.
     0.986
EEC90835.1
Hypothetical protein; Psort location: Cytoplasmic, score: 8.87.
 
      0.880
truB
tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
  
 
  0.851
dnaN
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 
 0.845
EEC89063.1
Putative ATP-dependent nuclease subunit A; ATP-dependent DNA helicase.
  
 
 0.797
EEC90994.1
UvrD/REP helicase; KEGG: sha:SH1046 3.9e-137 pcrA; ATP-depentend DNA helicase K03657; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.651
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 
 0.583
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
   
 
 0.566
EEC91200.1
Prevent-host-death family protein; Antitoxin component of a type II toxin-antitoxin (TA) system.
       0.530
trmU
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
  
    0.516
Your Current Organism:
Holdemanella biformis
NCBI taxonomy Id: 518637
Other names: Eubacterium biforme DSM 3989, H. biformis DSM 3989, Holdemanella biformis DSM 3989
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.