STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EEC90581.1Transcriptional regulator, MerR family; KEGG: eci:UTI89_C3737 3.0e-08 yhdM; Zn(II)-responsive regulator of ZntA. (218 aa)    
Predicted Functional Partners:
EEC91075.1
Diguanylate cyclase (GGDEF) domain protein; KEGG: eci:UTI89_C1612 6.9e-20 ydaM; hypothetical protein YdaM; Psort location: Cytoplasmic, score: 8.87.
  
 0.898
EEC90055.1
Class II glutamine amidotransferase; KEGG: gka:GK1431 0. glutamate synthaselarge subunit K00265; Psort location: Cytoplasmic, score: 8.87.
    
 0.868
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
  
 
 0.823
rpoD
RNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
  
 
 0.810
EEC90132.1
DnaJ domain protein; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.810
ribB
3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
    
  0.793
rpoC
DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.780
EEC90052.1
Glutamine synthetase, beta-grasp domain protein; KEGG: chy:CHY_0704 2.1e-83 glnA1; glutamine synthetase K01915; Psort location: Cytoplasmic, score: 9.98.
  
 
 0.720
EEC89555.1
KEGG: efa:EF2762 9.4e-33 holB; DNA polymerase III, delta prime subunit K02341; Psort location: Cytoplasmic, score: 8.87.
   
  0.695
dnaX
DNA polymerase III, subunit gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
   
  0.695
Your Current Organism:
Holdemanella biformis
NCBI taxonomy Id: 518637
Other names: Eubacterium biforme DSM 3989, H. biformis DSM 3989, Holdemanella biformis DSM 3989
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