Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
murDUDP-N-acetylmuramoylalanine/D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (457 aa)    
Predicted Functional Partners:
murG
Undecaprenyldiphospho-muramoylpentapeptidebeta-N -acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily.
 
  
 0.996
murC
UDP-N-acetylmuramate/alanine ligase; Cell wall formation; Belongs to the MurCDEF family.
 
 
 0.995
Smon_0025
TIGRFAM:UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-di aminopimelate/D-alanyl-D-alanylligase; PFAM: Mur ligase middle domain protein; cytoplasmic peptidoglycan synthetase domain protein; KEGG: bca:BCE_2244 UDP-N-acetylmuramoylalanyl-D- glutamyl-2,6-diaminopimelate--D-alanyl- D-alanyl ligase, degenerate.
 
  
 0.990
mraY
phospho-N-acetylmuramoyl-pentapeptide-transferas e; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily.
  
 0.984
murE
UDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily.
 
 
0.980
murI
Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.
 
  
 0.977
ddl
D-alanine/D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family.
 
 
 0.972
Smon_0028
PFAM: cell cycle protein; KEGG: cbg:CbuG_1883 cell division protein; Belongs to the SEDS family.
 
  
 0.961
murA
UDP-N-acetylglucosamine1- carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.
 
   
 0.850
Smon_0098
Polypeptide-transport-associated domain protein FtsQ-type; Essential cell division protein.
  
  
 0.849
Your Current Organism:
Streptobacillus moniliformis
NCBI taxonomy Id: 519441
Other names: S. moniliformis DSM 12112, Streptobacillus moniliformis ATCC 14647, Streptobacillus moniliformis DSM 12112, Streptobacillus moniliformis str. DSM 12112, Streptobacillus moniliformis strain DSM 12112
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