Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Smon_0565PFAM: heat shock protein DnaJ domain protein; KEGG: abu:Abu_1033 DnaJ domain-containing protein. (163 aa)    
Predicted Functional Partners:
Smon_0300
TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: cco:CCC13826_1933 pyruvate:ferredoxin (flavodoxin) oxidoreductase.
  
 0.937
Smon_1448
PFAM: AMP-dependent synthetase and ligase; phospholipid/glycerol acyltransferase; SMART: phospholipid/glycerol acyltransferase; KEGG: hha:Hhal_0052 AMP-dependent synthetase and ligase.
  
 0.833
grpE
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
  
 
 0.809
Smon_0610
Hypothetical protein.
  
 0.806
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 0.806
groL
Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
 0.779
Smon_0564
PFAM: Patatin; KEGG: shn:Shewana3_4351 patatin.
       0.770
Smon_0563
PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: lch:Lcho_4268 ABC transporter-related protein.
  
    0.746
Smon_0846
PFAM: Ankyrin; SMART: Ankyrin; KEGG: wpi:WPa_1379 ankyrin repeat domain protein.
   
 0.699
rplQ
TIGRFAM: ribosomal protein L17; PFAM: ribosomal protein L17; KEGG: rplQ; 50S ribosomal protein L17.
  
 
 0.698
Your Current Organism:
Streptobacillus moniliformis
NCBI taxonomy Id: 519441
Other names: S. moniliformis DSM 12112, Streptobacillus moniliformis ATCC 14647, Streptobacillus moniliformis DSM 12112, Streptobacillus moniliformis str. DSM 12112, Streptobacillus moniliformis strain DSM 12112
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