node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFR41770.1 | SFR42322.1 | SAMN04488070_0733 | SAMN04488070_0810 | Indole-3-glycerol phosphate synthase. | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.730 |
SFR41770.1 | SFR49930.1 | SAMN04488070_0733 | SAMN04488070_1512 | Indole-3-glycerol phosphate synthase. | Homoserine dehydrogenase. | 0.927 |
SFR41770.1 | SFR51137.1 | SAMN04488070_0733 | SAMN04488070_1641 | Indole-3-glycerol phosphate synthase. | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.915 |
SFR41770.1 | SFR60852.1 | SAMN04488070_0733 | SAMN04488070_2315 | Indole-3-glycerol phosphate synthase. | Phosphoserine phosphatase. | 0.867 |
SFR41770.1 | glyA | SAMN04488070_0733 | SAMN04488070_0845 | Indole-3-glycerol phosphate synthase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.905 |
SFR41770.1 | hisB | SAMN04488070_0733 | SAMN04488070_0807 | Indole-3-glycerol phosphate synthase. | Imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.797 |
SFR41770.1 | hisH | SAMN04488070_0733 | SAMN04488070_0808 | Indole-3-glycerol phosphate synthase. | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.633 |
SFR41770.1 | hisI | SAMN04488070_0733 | SAMN04488070_0811 | Indole-3-glycerol phosphate synthase. | phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family. | 0.907 |
SFR41770.1 | serC | SAMN04488070_0733 | SAMN04488070_0431 | Indole-3-glycerol phosphate synthase. | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.430 |
SFR42322.1 | SFR41770.1 | SAMN04488070_0810 | SAMN04488070_0733 | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Indole-3-glycerol phosphate synthase. | 0.730 |
SFR42322.1 | SFR49930.1 | SAMN04488070_0810 | SAMN04488070_1512 | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Homoserine dehydrogenase. | 0.771 |
SFR42322.1 | SFR51137.1 | SAMN04488070_0810 | SAMN04488070_1641 | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.771 |
SFR42322.1 | SFR60852.1 | SAMN04488070_0810 | SAMN04488070_2315 | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Phosphoserine phosphatase. | 0.846 |
SFR42322.1 | hisB | SAMN04488070_0810 | SAMN04488070_0807 | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.999 |
SFR42322.1 | hisH | SAMN04488070_0810 | SAMN04488070_0808 | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
SFR42322.1 | hisI | SAMN04488070_0810 | SAMN04488070_0811 | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
SFR49930.1 | SFR41770.1 | SAMN04488070_1512 | SAMN04488070_0733 | Homoserine dehydrogenase. | Indole-3-glycerol phosphate synthase. | 0.927 |
SFR49930.1 | SFR42322.1 | SAMN04488070_1512 | SAMN04488070_0810 | Homoserine dehydrogenase. | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.771 |
SFR49930.1 | SFR51137.1 | SAMN04488070_1512 | SAMN04488070_1641 | Homoserine dehydrogenase. | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.992 |
SFR49930.1 | SFR60852.1 | SAMN04488070_1512 | SAMN04488070_2315 | Homoserine dehydrogenase. | Phosphoserine phosphatase. | 0.916 |